INT252633

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.66
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) extracellular space (TNF)
signal transduction (TNF) extracellular region (TNF) cell death (Tnfrsf1b)
TNF (Homo sapiens)
Tnfrsf1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 26 95.92 Very High Very High Very High
Hyperalgesia 14 95.36 Very High Very High Very High
Eae 38 94.32 High High
rheumatoid arthritis 15 92.40 High High
metalloproteinase 2 90.52 High High
Inflammation 42 88.08 High High
cytokine 43 79.24 Quite High
Lasting pain 10 75.96 Quite High
Arthritis 18 72.76 Quite High
ischemia 28 69.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 35 99.20 Very High Very High Very High
Neuropathic Pain 148 95.92 Very High Very High Very High
Herpes Simplex Virus 4 95.76 Very High Very High Very High
Hyperalgesia 24 95.36 Very High Very High Very High
Injury 60 94.32 High High
Rheumatoid Arthritis 15 92.40 High High
INFLAMMATION 50 88.08 High High
Autoimmune Disease 1 86.96 High High
Death 21 85.48 High High
Stress 4 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, over-expressed p55 sTNFR (sTNFR2) binds to the mTNF of DRG and down-regulates overall production of TNF by reverse signaling, significantly reducing the allodynia and hyperalgesia responses to CCI [170,171].
mTNF Binding (binds) of sTNFR associated with hyperalgesia, allodynia and eae
1) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.82 Pain Relevance 0.55
As a result, over-expressed p55 sTNFR (sTNFR2) binds to the mTNF of DRG and down-regulates overall production of TNF by reverse signaling, significantly reducing the allodynia and hyperalgesia responses to CCI [170,171].
mTNF Binding (binds) of sTNFR2 associated with hyperalgesia, allodynia and eae
2) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.82 Pain Relevance 0.55
Once released, soluble TNF circulates as a homotrimer that will bind with one of two distinct receptors of 55-kDa (TNFR1) or 75-kDa (TNFR2) molecular weight.
TNF Binding (bind) of TNFR2
3) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.57 Pain Relevance 0.16
An alternate hypothesis is that TNFR2 may be responsible for the DNA fragmentation activity associated with TNF?
TNF Binding (associated) of TNFR2
4) Confidence 0.01 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.49 Pain Relevance 0
Both sTNF and tmTNF ligands interact with either of 2 distinct receptors—TNF receptor 1 (TNFR1, p55, CD120a) and TNF receptor 2 (TNFR2, p75, CD120b)—on a wide variety of cell types to mediate their biological functions [2], [3].
tmTNF Binding (interact) of TNFR2
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.96 Pain Relevance 0.28

General Comments

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