INT25264

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.17
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 130 99.04 Very High Very High Very High
Arthritis 40 98.80 Very High Very High Very High
anakinra 4 97.20 Very High Very High Very High
antagonist 1 94.44 High High
diclofenac 5 83.12 Quite High
Infliximab 9 80.92 Quite High
cINOD 24 68.68 Quite High
Inflammatory stimuli 2 67.20 Quite High
Inflammatory mediators 10 59.04 Quite High
methotrexate 14 57.76 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 132 99.04 Very High Very High Very High
Arthritis 48 98.80 Very High Very High Very High
Infection 4 85.60 High High
Congenital Anomalies 1 79.68 Quite High
INFLAMMATION 66 68.44 Quite High
Sepsis 2 20.80 Low Low
Asthma 4 18.20 Low Low
Disease 33 15.24 Low Low
Rhinitis 2 10.92 Low Low
Nasal Polyps 2 9.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the drugs had no effect on IL-1 alpha-induced decreases in radioactivity associated with phosphatidylcholine (PC), this result was interpreted as being due to an enhanced acylation of AA into PE and TG.
Neg (no) Regulation (effect) of Negative_regulation (decreases) of IL-1
1) Confidence 0.27 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2512925 Disease Relevance 0.07 Pain Relevance 0.22
To determine whether these MAPKs are involved in the IL-1-mediated downregulation of PPAR?
Spec (whether) Regulation (involved) of Spec (whether) Negative_regulation (downregulation) of IL-1-mediated
2) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.29 Pain Relevance 0.15
To assess the contribution of these pathways in the IL-1-mediated downregulation of PPAR?
Regulation (contribution) of Negative_regulation (downregulation) of IL-1-mediated
3) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.15 Pain Relevance 0.08
There has been great interest in the role of IL-1 inhibition in the treatment of systemic JRA.
Regulation (role) of Negative_regulation (inhibition) of IL-1 associated with arthritis
4) Confidence 0.12 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012273 Disease Relevance 0.65 Pain Relevance 0.57

General Comments

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