INT252645

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 13.12 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 156 99.98 Very High Very High Very High
Cancer 162 83.84 Quite High
Squamous Cell Carcinoma 24 50.00 Quite Low
Solid Tumor 48 45.16 Quite Low
Ataxia 12 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Telangiectasia 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Mouth Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we found that radiation-induced apoptosis increased among the cells lack of ATM expression compared with those cells that have impact ATM expression.
Positive_regulation (increased) of Gene_expression (expression) of ATM associated with apoptosis
1) Confidence 0.50 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.63 Pain Relevance 0
From flow cytometry, we found that the cells did not accumulate in the G2/M phase following irradiation in cells transfected with ATM AS-ODNs, which mean the reduced ATM expression resulted in the defective G2/M checkpoint control.
Positive_regulation (transfected) of Gene_expression (transfected) of ATM
2) Confidence 0.50 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.49 Pain Relevance 0
The results of clonogenic survival assay in vitro demonstrated that the cloning efficiency declined notably in cells which transfected with ATM AS-ODNs at the same dose of radiation (P < 0.05) compared with untreated cells or cells treated with control ODNs.
Positive_regulation (transfected) of Gene_expression (transfected) of ATM
3) Confidence 0.44 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.20 Pain Relevance 0
The SF2 of cells transfected with ATM AS-ODNs was 53.3 ± 3.1%, definitely lower than that of other cells, which indicated a significant increase in the radiosensitivity (P < 0.05; Figure. 3).
Positive_regulation (transfected) of Gene_expression (transfected) of ATM
4) Confidence 0.44 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.15 Pain Relevance 0
In the present study, we successfully transfected ATM AS-ODNs into SCCVII cells using liposome as delivery carrier, and detected the inhibitory expression of ATM at mRNA and protein level in SCCVII cells.
Positive_regulation (transfected) of Gene_expression (transfected) of ATM
5) Confidence 0.41 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.24 Pain Relevance 0
Expression of ATM in ATM AS-ODNs transfected SCCVII cells
Positive_regulation (transfected) of Gene_expression (Expression) of ATM
6) Confidence 0.41 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.64 Pain Relevance 0

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