INT25265

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 28.12
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
monocyte 6
plasma 3
myeloid progenitor cells 1
brains 1
white matter 1
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 207 99.90 Very High Very High Very High
drug abuse 51 91.92 High High
withdrawal 3 84.60 Quite High
anesthesia 2 84.32 Quite High
Bioavailability 7 83.52 Quite High
Central nervous system 128 81.84 Quite High
cva 2 78.88 Quite High
chemokine 57 72.08 Quite High
Sciatica 2 67.12 Quite High
corticosteroid 2 62.96 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2976 100.00 Very High Very High Very High
Dementia 209 99.70 Very High Very High Very High
Disease 219 99.24 Very High Very High Very High
Coagulation Disorder 4 98.88 Very High Very High Very High
Death 65 97.04 Very High Very High Very High
Disease Progression 58 93.20 High High
Infection 454 93.16 High High
Drug Dependence 51 91.92 High High
Syndrome 47 90.76 High High
Immunodeficiency 70 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of h-GAAP mRNA in different tissues was analyzed using Human Multiple Tissue cDNA panels I and II (Clontech, http://www.clontech.com) and semi-quantitative RT-PCR with Platinum PCR SuperMix (Invitrogen, http://www.invitrogen.com). cDNAs were amplified with h-GAAP specific primers.
Spec (analyzed) Transcription (presence) of h-GAAP
1) Confidence 0.45 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.62 Pain Relevance 0
In a prevalence survey conducted from September to December 1985, HIV antibodies were found in all the 4 patients with hemophilia treated with the batch number W87307, 955 I.U. of American commercial factor VIII concentrate supplied by Armour pharmaceutical Company U.S.A.
Transcription (found) of HIV associated with coagulation disorder and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.23 Published 1989 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 2513171 Disease Relevance 1.30 Pain Relevance 0.11
The antiviral response was similar among all raltegravir groups (mean decreases in log10 HIV RNA level of 1.93, 1.98, 1.66, and 2.16 copies/mL 100, 200, 400, and 600 mg twice daily, respectively) and was significantly greater compared with placebo (mean decreases in log10 HIV RNA ?
Transcription (level) of HIV associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.91 Pain Relevance 0
The HIV-1 Tat protein is essential for the initiation of HIV transcription from the integrated HIV genome (provirus) through exploitation
Transcription (transcription) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.14 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586134 Disease Relevance 1.73 Pain Relevance 0.28
of host proteins and recent evidence also points to pathways that lead to chromatin remodeling as a component of HIV transcription.
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.12 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586134 Disease Relevance 1.62 Pain Relevance 0.20
studies showed that chromatin remodeling was involved in HIV-1 basal transcription as well as in response to TNF-?
Transcription (transcription) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.12 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586134 Disease Relevance 1.69 Pain Relevance 0.26
The HIV-1 Tat protein is essential for the initiation of HIV transcription from the integrated HIV genome (provirus) through exploitation
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.12 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586134 Disease Relevance 1.66 Pain Relevance 0.17
The HIV-1 Tat protein is essential for the initiation of HIV transcription from the integrated HIV genome (provirus) through exploitation
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.12 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586134 Disease Relevance 1.65 Pain Relevance 0.17
Transcription of the HIV-1 LTR is a highly complex process that involves the interplay of host and viral transcription factors coupled with a wide array of signaling pathways that are activated by extracellular stimuli.
Transcription (Transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.22 Pain Relevance 0.04
Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage varies considerably with the differentiation stage of the cell.
Transcription (transcription) of HIV in monocyte associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.49 Pain Relevance 0
The importance of the Sp sites also varies depending on the differentiation stage of the cell; in unstimulated monocytes, mutation of the Sp sites reduces LTR activity, whereas in MDMs, transcription of HIV and replication of SIVmac are abolished when these critical binding sites are knocked out [83-86].
Transcription (transcription) of HIV in monocytes associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.05 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.45 Pain Relevance 0
Genetic variation within the LTR also plays a role in HIV-1 transcription as HIV-associated disease progresses.
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection and disease
12) Confidence 0.05 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.79 Pain Relevance 0
B [271], C/EBP [272], and Tat [244,273] to enhance transcription of the HIV-1 genome.
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.05 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.40 Pain Relevance 0
C/EBP can also act synergistically with Sp proteins to activate transcription of the HIV-1 LTR [185].
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.05 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.52 Pain Relevance 0
HIV transcripts were more abundant in subcortical white matter than in the basal ganglia, cortex, or deep white matter.
Transcription (transcripts) of HIV in white matter associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.05 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.83 Pain Relevance 0.26
To determine which cytokines are produced in the nervous system and to identify any correlations with dementia, cytokine and HIV messenger RNA expression was analyzed by reverse transcriptase-polymerase chain reaction in the brains from 24 HIV-infected patients with and without dementia and 9 HIV-uninfected control subjects.
Transcription (expression) of HIV in brains associated with dementia, acquired immune deficiency syndrome or hiv infection and cytokine
16) Confidence 0.05 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.55 Pain Relevance 0.18
As these cells differentiate in the marrow and periphery, the levels of HIV-1 transcription may increase, resulting in the expression of toxic viral proteins and enhanced replication [36] and Alexaki, Shah, and Wigdahl, unpublished results).
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.47 Pain Relevance 0.11
Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage is a complex process involving the interaction of numerous factors that are expressed in a differentiation-dependent manner and whose activity is regulated by both cellular differentiation and extracellular signaling pathways.
Transcription (transcription) of HIV in monocyte associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.30 Pain Relevance 0
By itself, Sp3 can weakly activate HIV-1 transcription; however, in the presence of the strong activator Sp1, it competes for binding to the LTR and inhibits activation by Sp1 [66,68,69].
Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.32 Pain Relevance 0
Unstimulated peripheral monocytes and myeloid progenitor cells support low levels of viral replication and transcription in response to cellular activation [27,36,48-54], whereas differentiated MDMs have increased viral replication but either do not respond to [45] or downregulate HIV transcription [48,55] in response to cellular stimulation.
Transcription (transcription) of HIV in myeloid progenitor cells associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.81 Pain Relevance 0

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