INT25266

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 15.89
Pain Relevance 14.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 8
microglia 7
keratinocytes 4
muscle 4
leukocyte 4
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 365 100.00 Very High Very High Very High
cytokine 142 100.00 Very High Very High Very High
rheumatoid arthritis 192 99.92 Very High Very High Very High
substance P 71 99.92 Very High Very High Very High
Cannabinoid 9 99.62 Very High Very High Very High
COX2 1 99.62 Very High Very High Very High
Clonidine 8 99.58 Very High Very High Very High
Kinase C 6 98.74 Very High Very High Very High
Fibrositis 98 98.32 Very High Very High Very High
Neuropeptide 11 98.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 439 100.00 Very High Very High Very High
Cancer 24 100.00 Very High Very High Very High
Necrosis 19 100.00 Very High Very High Very High
Rheumatoid Arthritis 192 99.92 Very High Very High Very High
Alzheimer's Dementia 2 99.88 Very High Very High Very High
Influenza Virus Infection 2 99.52 Very High Very High Very High
Hepatitis 1 98.84 Very High Very High Very High
Stress 3 98.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.40 Very High Very High Very High
Fibromyalgia 95 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP at concentrations > or = 2 mM promoted IL-1 beta release from these cells.
Positive_regulation (promoted) of Localization (release) of IL-1
1) Confidence 0.69 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.23 Pain Relevance 0.26
In conclusion, this study shows that PKC signal pathway seems to be involved in the pyocyanin-mediated upregulation of the IL-1beta and PDBu-induced IL-8 release in BEAS-2B cells.
Positive_regulation (upregulation) of Localization (release) of IL-1beta in BEAS-2B associated with kinase c
2) Confidence 0.67 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.29 Pain Relevance 0.37
We found a significant enhancement of TNF-alpha and IL-1beta release in lipopolysaccharide (LPS)-stimulated whole blood cultures after induction of anesthesia.
Positive_regulation (enhancement) of Localization (release) of IL-1beta in blood associated with anesthesia
3) Confidence 0.67 Published 2003 Journal Shock Section Abstract Doc Link 12923491 Disease Relevance 0.38 Pain Relevance 0.79
Morphine pre-treatment potentiates the effects of LPS on endothelial cell viability, and on LPS induction of IL-1beta secretion from 1alpha, 25-dihydroxy-vitamin D3-treated HL-60 human leukemia cells.
Positive_regulation (induction) of Localization (secretion) of IL-1beta in endothelial cell associated with leukemia and morphine
4) Confidence 0.67 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727765 Disease Relevance 0.32 Pain Relevance 0.82
Activation of P2X7 receptors is the mechanism by which ATP stimulates the rapid maturation and release of IL-1beta from macrophages and microglial cells.
Positive_regulation (stimulates) of Localization (release) of IL-1beta in microglial cells
5) Confidence 0.67 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19464323 Disease Relevance 0.54 Pain Relevance 0.59
Nordihydroguaiaretic acid inhibited the level of the secreted form of IL-1 beta, but tended to increase the cell-associated level.
Positive_regulation (increase) of Localization (secreted) of IL-1 beta
6) Confidence 0.50 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.21 Pain Relevance 0.28
In general, after an insult to the body both IL-1?
Positive_regulation (insult) of Localization (body) of IL-1 in body
7) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.57 Pain Relevance 0.40
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (mediated) of Localization (release) of IL-1beta
8) Confidence 0.49 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (mediated) of Localization (release) of interleukin-1beta
9) Confidence 0.49 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
Furthermore, myoblasts can secrete MCP-1, eotaxin, and IP-10, while treatment with MCP-1 caused secretion of IL-1beta, eotaxin and IP-10.
Positive_regulation (caused) of Localization (secretion) of IL-1beta in myoblasts
10) Confidence 0.49 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.15 Pain Relevance 0.72
The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.
Positive_regulation (increased) of Localization (release) of IL-1beta associated with kinase c
11) Confidence 0.49 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.28 Pain Relevance 0.37
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (triggers) of Localization (release) of interleukin-1beta
12) Confidence 0.49 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (triggers) of Localization (release) of IL-1beta
13) Confidence 0.49 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
These processes involve activation of microglia by amyloid-beta leading to release of pro-inflammatory cytokines including IL-1beta, IL-6, and TNF-alpha among others.
Positive_regulation (leading) of Localization (release) of IL-1beta in microglia associated with inflammation, alzheimer's dementia and cytokine
14) Confidence 0.49 Published 2005 Journal Int Rev Psychiatry Section Abstract Doc Link 16401549 Disease Relevance 1.33 Pain Relevance 0.48
We investigated the hypothesis that oral clonidine premedication would decrease the release of proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha, and stress hormones cortisol and adrenocorticotropic hormone (ACTH), in patients who underwent total abdominal hysterectomy.
Positive_regulation (decrease) of Localization (release) of IL-1beta associated with stress, necrosis, cancer, cytokine and clonidine
15) Confidence 0.49 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10825337 Disease Relevance 0.30 Pain Relevance 0.34
Discal cells were isolated, cultures and culture supernatants immunochemically analysed for IL-1beta and IL-1Ra secretion.
Spec (analysed) Positive_regulation (analysed) of Spec (analysed) Localization (secretion) of IL-1beta in Discal cells
16) Confidence 0.49 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.09 Pain Relevance 0.20
Previously, ATP was shown to promote the release and proteolytic maturation of IL-1 beta from LPS-stimulated murine peritoneal macrophages.
Positive_regulation (promote) of Localization (release) of IL-1 in peritoneal macrophages
17) Confidence 0.46 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.25 Pain Relevance 0.19
Although donor and CP PBMC responded equally to LPS, PACAP-mediated counteraction of LPS-induced cytokine response was switched from inhibiting TNF-alpha to decreasing IL-1beta and increasing IL-10 secretion.
Positive_regulation (increasing) of Localization (secretion) of IL-1beta in PBMC associated with chronic pancreatitis and cytokine
18) Confidence 0.45 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.11 Pain Relevance 0.98
Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.
Positive_regulation (stimulus-induced) of Localization (secretion) of IL-1 in leukocyte
19) Confidence 0.40 Published 1993 Journal Acta Anaesthesiol Scand Section Title Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.47
NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2.
Positive_regulation (induced) of Localization (release) of IL-1 in astrocytes associated with cox2
20) Confidence 0.34 Published 1997 Journal Brain Res. Section Title Doc Link 9449430 Disease Relevance 0.90 Pain Relevance 0.54

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