INT252717

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.53
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)
Anatomy Link Frequency
hepatocytes 2
SAMSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 2 97.66 Very High Very High Very High
Inflammation 48 93.44 High High
Inflammatory response 11 81.68 Quite High
cytokine 21 57.96 Quite High
alcohol 5 55.24 Quite High
Bile 3 17.56 Low Low
fibrosis 19 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alcoholic Liver Diseases 19 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 12 100.00 Very High Very High Very High
Stress 107 95.60 Very High Very High Very High
INFLAMMATION 57 93.44 High High
Disease 18 91.20 High High
Injury 46 82.84 Quite High
Necrosis 12 79.20 Quite High
Death 55 72.24 Quite High
Apoptosis 55 71.80 Quite High
Liver Disease 43 67.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of intracellular oxidative stress may also be reached within hepatocytes damaged by specific toxins (for example, CCl4 and acetaminophen) or aetiologies (for example, high levels of transition metal ions) or because of individual differences, including induction of peculiar cytochrome P450 isoforms (such as CYP2E1 in ASH/ALD or NASH), antioxidant status or even genetic polymorphisms.
Positive_regulation (induction) of Gene_expression (/) of NASH in hepatocytes associated with stress, nash(non-alcoholic steatohepatitis), paracetamol and alcoholic liver diseases
1) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.53 Pain Relevance 0.24

General Comments

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