INT252737

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.97
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
reticulum 1
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 7 92.40 High High
alcohol 10 91.44 High High
Inflammation 133 86.40 High High
palliative 7 82.56 Quite High
Spinal cord 5 72.64 Quite High
ischemia 4 67.60 Quite High
fibrosis 38 63.00 Quite High
tolerance 3 62.88 Quite High
Antihistamine 3 43.12 Quite Low
Kinase C 47 13.20 Low Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 90 99.98 Very High Very High Very High
Cancer 229 99.84 Very High Very High Very High
Thyroid Neoplasm 352 99.68 Very High Very High Very High
Infection 83 96.84 Very High Very High Very High
Hepatocellular Cancer 5 95.00 High High
Targeted Disruption 18 91.20 High High
Solid Tumor 12 91.04 High High
Stress 214 89.20 High High
Disease 188 89.04 High High
Neurodegenerative Disease 4 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant reductions from baseline were detected in the expression of c-raf1 [92].
Gene_expression (expression) of c-raf
1) Confidence 0.58 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.88 Pain Relevance 0
This gene partially overlaps with the raf1 proto-oncogene in antisense transcriptional orientation [17].
Gene_expression (proto) of raf1
2) Confidence 0.29 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3022923 Disease Relevance 0.34 Pain Relevance 0
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (/) of Raf-1
3) Confidence 0.29 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.06 Pain Relevance 0
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (/) of Raf-1
4) Confidence 0.29 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.08 Pain Relevance 0
The Raf-1/Mitogen-Regulated Extracellular Kinase (MEK)/Extracellular-Regulated Kinase (ERK) Signaling Pathway
Gene_expression (The) of Raf-1
5) Confidence 0.29 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.06 Pain Relevance 0
More importantly, ectopic raf-1 expression led to significant MTC growth suppression both in vitro and in a mouse xenograft model of MTC [40–43].
Gene_expression (expression) of raf-1 associated with thyroid neoplasm
6) Confidence 0.26 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.98 Pain Relevance 0
Preclinical studies of this drug have shown inhibition of tumour growth, more than 50% inhibition of raf-1 expression in tumour xenografts and increased sensitization of tumour cells to radiation and to chemotherapeutic agents [101, 102].
Gene_expression (expression) of raf-1 associated with cancer
7) Confidence 0.23 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.18 Pain Relevance 0.11
ISIS 5132 was shown not only to decrease c-raf expression but also to increase tumour sensitivity [91].
Gene_expression (expression) of c-raf associated with cancer
8) Confidence 0.18 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.69 Pain Relevance 0
Alternatively, recombinant antigens such as the envelope glycoprotein E [29], virus-like particles (VLP) [30], or the non-structural NS1 [31], NS3 and NS5 [32] proteins may presently be produced and purified in large scale for use in different assay formats in the absence of particular containment facilities.
Gene_expression (produced) of NS5
9) Confidence 0.13 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2878977 Disease Relevance 0.14 Pain Relevance 0
Other researchers have provided similar evidence for the HCV non-structural protein 5A (NS5A), which has been shown to associate with the membranes of endoplasmic reticulum (ER) and increase generation of ROS and activation of NF-?
Gene_expression (non) of NS5A in reticulum associated with hepatitis c virus infection
10) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.03 Pain Relevance 0.11
First, only some HCV-related proteins, such as NS5A, NS3 and HCV core protein, are likely to play roles in mediating redox perturbations, which can include increased generation of both ROS and RNS, iNOS and COX-2 (NS5A and C).
Gene_expression (generation) of NS5A associated with hepatitis c virus infection
11) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.30 Pain Relevance 0.07
The phosphorylation levels of Raf-1 and ERKs were dramatically increased in BDNF-transfected hUCB-MSCs at 7 days of induction (Figure 8C).


Gene_expression (levels) of Raf-1
12) Confidence 0.07 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.22 Pain Relevance 0.12

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