INT252743

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.68
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
liver 1
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 22 56.64 Quite High
fibrosis 38 49.00 Quite Low
Inflammation 96 40.72 Quite Low
cytokine 42 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatty Liver 48 96.76 Very High Very High Very High
Stress 214 96.48 Very High Very High Very High
Injury 92 86.08 High High
Cirrhosis 90 77.68 Quite High
Nash(non-alcoholic Steatohepatitis) 24 77.64 Quite High
Insulin Resistance 4 74.48 Quite High
Apoptosis 110 60.00 Quite High
INFLAMMATION 114 56.64 Quite High
Liver Disease 86 54.64 Quite High
Hepatitis C Virus Infection 54 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxidative stress and related reactive intermediates may contribute, as proposed for ethanol, to the genesis of steatosis by negatively affecting secretion of lipoproteins (either by enhancing degradation of Apo-B100 or by affecting lipoprotein glycosylation in the Golgi apparatus) [135,140] or even by interfering with the regulation of lipid synthesis by the sterol regulatory element binding protein 1 (SREBP-1) or the peroxisome proliferator-activated receptor ?
Protein_catabolism (degradation) of Apo-B100 associated with stress
1) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.75 Pain Relevance 0
Third, ethanol-induced oxidative stress is likely to contribute to liver steatosis found in alcoholics [138] by causing an impairment in either mitochondrial lipid oxidation [139] or lipoprotein secretions, the latter being related to enhanced degradation of ApoB100 [140] and/or oxidative alteration of lipoprotein glycosilation in Golgi apparatus [135].
Protein_catabolism (degradation) of ApoB100 in liver associated with fatty liver and stress
2) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.93 Pain Relevance 0.03

General Comments

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