INT252745

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.62
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
reticulum 2
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 96 85.32 High High
fibrosis 38 61.92 Quite High
alcohol 10 49.44 Quite Low
cytokine 42 5.00 Very Low Very Low Very Low
Inflammatory response 22 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 54 99.44 Very High Very High Very High
Thyroid Neoplasm 88 98.04 Very High Very High Very High
Infection 10 95.76 Very High Very High Very High
Hepatocellular Cancer 2 93.92 High High
Targeted Disruption 6 90.12 High High
INFLAMMATION 114 85.32 High High
Stress 214 84.24 Quite High
Injury 92 77.88 Quite High
Cancer 40 77.56 Quite High
Liver Cancer 2 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In MTC cells in vitro, Kunnimalaiyaan et al. [47] have demonstrated that ZM336372 treatment resulted in increasing Raf-1 activation as measured by phosphorylation of ERK1/2.
Positive_regulation (increasing) of Positive_regulation (activation) of Raf-1 associated with thyroid neoplasm
1) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.69 Pain Relevance 0
Other researchers have provided similar evidence for the HCV non-structural protein 5A (NS5A), which has been shown to associate with the membranes of endoplasmic reticulum (ER) and increase generation of ROS and activation of NF-?
Positive_regulation (generation) of Positive_regulation (activation) of NS5A in reticulum associated with hepatitis c virus infection
2) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.05 Pain Relevance 0.11
NS5A-mediated activation of NF-?
Positive_regulation (mediated) of Positive_regulation (activation) of NS5A
3) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.89 Pain Relevance 0.10

General Comments

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