INT252749

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1)
Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)
Anatomy Link Frequency
hepatocytes 2
ACO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 47.56 Quite Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 107 86.12 High High
Iron Overload 5 82.48 Quite High
Injury 46 79.88 Quite High
Fibrosis 37 61.16 Quite High
Alcoholic Liver Diseases 19 57.52 Quite High
Nash(non-alcoholic Steatohepatitis) 12 56.24 Quite High
Fatty Liver 24 56.04 Quite High
Infection 5 55.76 Quite High
Hepatitis C Virus Infection 27 55.36 Quite High
Wound Healing 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another concept should be recalled: intracellular levels of iron are usually carefully controlled (as in hepatocytes or macrophages) by means of iron binding to cytoplasmic Iron regulatory proteins (IRP-1 and IRP-2) and the expression of genes involved in iron homeostasis through the binding of IRPs to Iron responsive element (IRE) sequences, including those for transferrin receptor (TfR) and ferritin (Ft).
Regulation (involved) of Gene_expression (expression) of IRP-1 in hepatocytes
1) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.90 Pain Relevance 0

General Comments

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