INT252757

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.74
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PTPN6) cell proliferation (PTPN6) cytosol (PTPN6)
nucleus (PTPN6) cytoplasm (PTPN6)
Anatomy Link Frequency
platelets 1
T lymphocytes 1
PTPN6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 81.68 Quite High
chemokine 6 65.44 Quite High
cytokine 21 64.84 Quite High
Inflammation 48 64.44 Quite High
Inflammatory response 11 61.68 Quite High
dexamethasone 1 57.40 Quite High
addiction 3 50.00 Quite Low
fibrosis 19 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 52 74.12 Quite High
Apoptosis 70 65.44 Quite High
INFLAMMATION 59 64.44 Quite High
Stress 107 60.92 Quite High
Purpura 1 60.92 Quite High
Thrombocytopenia 1 60.60 Quite High
Death 56 58.36 Quite High
Glioma 26 50.00 Quite Low
Wound Healing 13 50.00 Quite Low
Retinoblastoma 1 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Negative_regulation (downregulation) of SHP1
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
Although both SHP-1 and SHP-2 are said to be positive regulators of signal transduction, their specific functions in platelets are not yet known.
Negative_regulation (regulators) of SHP-1 in platelets
2) Confidence 0.07 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.12 Pain Relevance 0.10
PTPi I and PTPi II have both been shown to be potent inhibitors of Shp1, a phosphatase which inhibits VEGFR2 phosphorylation, and hence is a negative signaling component (36).
Negative_regulation (inhibitors) of Shp1
3) Confidence 0.06 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.12 Pain Relevance 0
Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257].
Negative_regulation (modulation) of SHP-1 in T lymphocytes
4) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

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