INT252757
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43]. | |||||||||||||||
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Although both SHP-1 and SHP-2 are said to be positive regulators of signal transduction, their specific functions in platelets are not yet known. | |||||||||||||||
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PTPi I and PTPi II have both been shown to be potent inhibitors of Shp1, a phosphatase which inhibits VEGFR2 phosphorylation, and hence is a negative signaling component (36). | |||||||||||||||
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Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257]. | |||||||||||||||
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General Comments
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