INT252757

Context Info Confidence 0.10 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.74 Pain Relevance 0.25

cell differentiation (PTPN6) cell proliferation (PTPN6) cytosol (PTPN6) nucleus (PTPN6) cytoplasm (PTPN6)

Anatomy Link Frequency platelets 1 T lymphocytes 1 PTPN6 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 2 81.68 chemokine 6 65.44 cytokine 21 64.84 Inflammation 48 64.44 Inflammatory response 11 61.68 dexamethasone 1 57.40 addiction 3 50.00 fibrosis 19 5.00 alcohol 5 5.00 Kinase C 3 5.00

Disease Link Frequency Relevance Heat Cancer 52 74.12 Apoptosis 70 65.44 INFLAMMATION 59 64.44 Stress 107 60.92 Purpura 1 60.92 Thrombocytopenia 1 60.60 Death 56 58.36 Glioma 26 50.00 Wound Healing 13 50.00 Retinoblastoma 1 46.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].

Negative_regulation (downregulation) of SHP1

1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0

Although both SHP-1 and SHP-2 are said to be positive regulators of signal transduction, their specific functions in platelets are not yet known.

Negative_regulation (regulators) of SHP-1 in platelets

2) Confidence 0.07 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.12 Pain Relevance 0.10

PTPi I and PTPi II have both been shown to be potent inhibitors of Shp1, a phosphatase which inhibits VEGFR2 phosphorylation, and hence is a negative signaling component (36).

Negative_regulation (inhibitors) of Shp1

3) Confidence 0.06 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.12 Pain Relevance 0

Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257].

Negative_regulation (modulation) of SHP-1 in T lymphocytes

4) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

This test has worked.