INT252768

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Tnfrsf1a) extracellular space (TNF, Tnfrsf1a) extracellular region (TNF, Tnfrsf1a)
plasma membrane (TNF, Tnfrsf1a) nucleus (Tnfrsf1a) intracellular (TNF)
TNF (Homo sapiens)
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 74.00 Quite High
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 55 99.44 Very High Very High Very High
Death 55 99.22 Very High Very High Very High
Liver Disease 43 77.44 Quite High
INFLAMMATION 57 74.00 Quite High
Wound Healing 12 50.00 Quite Low
Necrosis 12 7.64 Low Low
Stress 107 5.00 Very Low Very Low Very Low
Injury 46 5.00 Very Low Very Low Very Low
Cirrhosis 45 5.00 Very Low Very Low Very Low
Fibrosis 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of pathways leading to increased mitochondrial ROS generation and related to cell death (apoptotic or not) may be elicited by TNF, mainly by acting on the TNF receptor TNFRI, but a significant role for ROS has also been described in the activation of Fas as well as other death receptors, such as DR-4 and DR-5 [107].
TNF Regulation (acting) of TNFRI associated with apoptosis and death
1) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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