INT252773

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0

cell differentiation (ROS1) cell proliferation (ROS1) extracellular space (COL1A1) extracellular region (COL1A1) plasma membrane (ROS1) cytoplasm (COL1A1)

ROS1 (Homo sapiens) COL1A1 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 6 5.88 Inflammation 48 5.00 cytokine 21 5.00 fibrosis 19 5.00 Inflammatory response 11 5.00 alcohol 5 5.00 Bile 3 5.00 Paracetamol 2 5.00 COX2 1 5.00 Nerve growth factor 1 5.00

Disease Link Frequency Relevance Heat Stress 107 82.08 Liver Disease 43 72.08 Fibrosis 37 63.72 Wound Healing 12 50.00 Cirrhosis 45 37.76 INFLAMMATION 57 5.00 Death 55 5.00 Apoptosis 55 5.00 Injury 46 5.00 Hepatitis C Virus Infection 27 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Up-regulation of pro-collagen type I by both ROS and HNE in activated HSC/MFs is a relevant finding that has been confirmed by several different laboratories using either cells of human or rat origin.

ROS Positive_regulation (regulation) of pro-collagen type I

1) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.57 Pain Relevance 0

General Comments

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