INT252778

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.05
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RAF1, ROS1) plasma membrane (RAF1, ROS1) cell differentiation (ROS1)
mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
Anatomy Link Frequency
reticulum 2
RAF1 (Homo sapiens)
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 85.32 High High
fibrosis 19 61.92 Quite High
alcohol 5 42.24 Quite Low
cytokine 21 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 27 99.44 Very High Very High Very High
Infection 5 95.76 Very High Very High Very High
Hepatocellular Cancer 1 93.92 High High
Targeted Disruption 3 90.12 High High
INFLAMMATION 57 85.32 High High
Injury 46 77.88 Quite High
Stress 107 77.04 Quite High
Liver Cancer 1 62.80 Quite High
Fibrosis 37 61.92 Quite High
Hepatitis 1 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other researchers have provided similar evidence for the HCV non-structural protein 5A (NS5A), which has been shown to associate with the membranes of endoplasmic reticulum (ER) and increase generation of ROS and activation of NF-?
NS5A Positive_regulation (increase) of Positive_regulation (activation) of ROS in reticulum associated with hepatitis c virus infection
1) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.05 Pain Relevance 0.11

General Comments

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