INT252778

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 2.05 Pain Relevance 0.11

cell proliferation (RAF1, ROS1) plasma membrane (RAF1, ROS1) cell differentiation (ROS1) mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)

Anatomy Link Frequency reticulum 2 RAF1 (Homo sapiens) ROS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 48 85.32 fibrosis 19 61.92 alcohol 5 42.24 cytokine 21 5.00 Inflammatory response 11 5.00 chemokine 6 5.00 Bile 3 5.00 Paracetamol 2 5.00 COX2 1 5.00 Nerve growth factor 1 5.00

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 27 99.44 Infection 5 95.76 Hepatocellular Cancer 1 93.92 Targeted Disruption 3 90.12 INFLAMMATION 57 85.32 Injury 46 77.88 Stress 107 77.04 Liver Cancer 1 62.80 Fibrosis 37 61.92 Hepatitis 1 61.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Other researchers have provided similar evidence for the HCV non-structural protein 5A (NS5A), which has been shown to associate with the membranes of endoplasmic reticulum (ER) and increase generation of ROS and activation of NF-?

NS5A Positive_regulation (increase) of Positive_regulation (activation) of ROS in reticulum associated with hepatitis c virus infection

1) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.05 Pain Relevance 0.11

General Comments

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