INT252780

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (CREB1, PPP2R4) nucleus (CREB1, PPP2R4) isomerase activity (PPP2R4)
nucleoplasm (CREB1) mitochondrion (CREB1) cytoplasm (PPP2R4)
CREB1 (Homo sapiens)
PPP2R4 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 5 74.08 Quite High
Inflammation 48 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 107 99.78 Very High Very High Very High
Hepatitis B Virus Infection 2 99.02 Very High Very High Very High
Hepatitis C Virus Infection 27 98.54 Very High Very High Very High
Alcoholic Liver Diseases 19 98.16 Very High Very High Very High
Injury 46 98.06 Very High Very High Very High
Targeted Disruption 3 89.52 High High
Apoptosis 55 87.40 High High
Fatty Liver 24 82.40 Quite High
Chronic Hepatitis 4 72.16 Quite High
Death 55 67.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, it has been reported that activation of the Gadd153 gene by HCV in HCV replicon cells is able to sensitizes these cells to oxidant injury [217] and that both HCV and, interestingly, HBV proteins are able to induce ER stress and to up-regulate protein phosphatase 2A (PP2A) through activation of CREB [218].
Positive_regulation (activation) of CREB Positive_regulation (regulate) of PP2A associated with stress, injury, hepatitis b virus infection and hepatitis c virus infection
1) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.71 Pain Relevance 0.04

General Comments

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