INT252784

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) extracellular space (COL1A1)
extracellular region (COL1A1) plasma membrane (ROS1) cytoplasm (COL1A1)
Anatomy Link Frequency
apoptotic cell 2
ROS1 (Homo sapiens)
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 22 94.94 High High
Inflammation 96 80.60 Quite High
fibrosis 38 66.08 Quite High
cytokine 42 52.96 Quite High
chemokine 12 38.16 Quite Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 110 99.12 Very High Very High Very High
Liver Disease 86 95.28 Very High Very High Very High
INFLAMMATION 114 94.76 High High
Stress 214 89.88 High High
Fibrosis 74 71.52 Quite High
Cirrhosis 90 66.56 Quite High
Wound Healing 24 50.00 Quite Low
Disease 36 47.32 Quite Low
Alcoholic Liver Diseases 38 45.44 Quite Low
Injury 92 42.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, impaired disposal of apoptotic cells and/or bodies may, at the same time: further increase the inflammatory response because of post-apoptotic cell lysis; maintain conditions that further sustain development of aPL-Ab; and act as a pro-fibrogenic stimulus, as shown by already cited studies in which phagocytosis of apoptotic bodies by HSC/MFs resulted in the NOX- and ROS-dependent increased stimulation of pro-collagen type I synthesis [97,322].


ROS-dependent Positive_regulation (increased) of Gene_expression (synthesis) of pro-collagen type I in apoptotic cell associated with inflammatory response and apoptosis
1) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.29 Pain Relevance 0.24
HNE and ROS can up-regulate pro-collagen type I expression in HSC/MFs: a puzzle that in the end makes sense
ROS Positive_regulation (regulate) of Gene_expression (expression) of pro-collagen type I
2) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.58 Pain Relevance 0

General Comments

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