INT252791

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IREB2, TFRC) endosome (TFRC) aging (TFRC)
transmembrane transport (TFRC) cytoplasm (IREB2) cytosol (IREB2)
Anatomy Link Frequency
hepatocytes 2
IREB2 (Homo sapiens)
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 96 47.16 Quite Low
cytokine 42 5.00 Very Low Very Low Very Low
fibrosis 38 5.00 Very Low Very Low Very Low
Inflammatory response 22 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 214 85.72 High High
Iron Overload 10 82.08 Quite High
Injury 92 79.48 Quite High
Fibrosis 74 60.76 Quite High
Alcoholic Liver Diseases 38 57.12 Quite High
Nash(non-alcoholic Steatohepatitis) 24 55.84 Quite High
Fatty Liver 48 55.64 Quite High
Infection 10 55.36 Quite High
Hepatitis C Virus Infection 54 54.96 Quite High
Wound Healing 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another concept should be recalled: intracellular levels of iron are usually carefully controlled (as in hepatocytes or macrophages) by means of iron binding to cytoplasmic Iron regulatory proteins (IRP-1 and IRP-2) and the expression of genes involved in iron homeostasis through the binding of IRPs to Iron responsive element (IRE) sequences, including those for transferrin receptor (TfR) and ferritin (Ft).
IRP-2 Binding (binding) of transferrin receptor in hepatocytes
1) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.91 Pain Relevance 0
Another concept should be recalled: intracellular levels of iron are usually carefully controlled (as in hepatocytes or macrophages) by means of iron binding to cytoplasmic Iron regulatory proteins (IRP-1 and IRP-2) and the expression of genes involved in iron homeostasis through the binding of IRPs to Iron responsive element (IRE) sequences, including those for transferrin receptor (TfR) and ferritin (Ft).
IRP-2 Binding (binding) of TfR in hepatocytes
2) Confidence 0.02 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.91 Pain Relevance 0

General Comments

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