INT252808

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, NOX1) plasma membrane (TNF, NOX1) intracellular (TNF)
extracellular matrix organization (TNF) response to stress (NOX1) extracellular space (TNF)
Anatomy Link Frequency
liver 1
TNF (Homo sapiens)
NOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 75.56 Quite High
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 55 100.00 Very High Very High Very High
Stress 107 81.44 Quite High
INFLAMMATION 57 75.56 Quite High
Apoptosis 55 74.64 Quite High
Liver Disease 43 73.52 Quite High
Wound Healing 12 50.00 Quite Low
Injury 46 5.00 Very Low Very Low Very Low
Cirrhosis 45 5.00 Very Low Very Low Very Low
Fibrosis 37 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, TNF (Figure 23) may even lead to ROS-dependent and JNK-mediated necrotic cell death through the activation of Nox1: however, this has been described in fibroblasts and, at present, we do not know whether it may apply to hepatocytes or other liver cell populations [195,202].


TNF Positive_regulation (activation) of Nox1 in liver associated with death
1) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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