INT252826

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.17
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) aging (CCL2) cytoplasm (CCL2)
cell proliferation (ROS1) extracellular space (CCL2) signal transduction (CCL2)
Anatomy Link Frequency
monocytes 4
macrophages 1
Kupffer cells 1
ROS1 (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 33 87.36 High High
fibrosis 57 87.12 High High
cytokine 63 60.40 Quite High
Inflammation 144 55.84 Quite High
chemokine 18 13.68 Low Low
alcohol 15 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 135 94.20 High High
INFLAMMATION 171 87.36 High High
Stress 321 72.88 Quite High
Fibrosis 111 70.16 Quite High
Liver Disease 129 58.00 Quite High
Wound Healing 36 50.00 Quite Low
Injury 138 44.00 Quite Low
Apoptosis 165 40.16 Quite Low
Death 165 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 81 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, both ROS and HNE have been shown to up-regulate MCP-1 expression in vivo and in vitro, and then to sustain recruitment/activation of monocytes/macrophages and Kupffer cells as well as to attract HSC/MFs [76,273,274].


ROS Regulation (regulate) of Gene_expression (expression) of MCP-1 in monocytes
1) Confidence 0.20 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.72 Pain Relevance 0.21
Indeed, both ROS and HNE have been shown to up-regulate MCP-1 expression in vivo and in vitro, and then to sustain recruitment/activation of monocytes/macrophages and Kupffer cells as well as to attract HSC/MFs [76,273,274].


ROS Regulation (regulate) of in macrophages Gene_expression (expression) of MCP-1 in monocytes
2) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.72 Pain Relevance 0.21
Indeed, both ROS and HNE have been shown to up-regulate MCP-1 expression in vivo and in vitro, and then to sustain recruitment/activation of monocytes/macrophages and Kupffer cells as well as to attract HSC/MFs [76,273,274].


ROS Regulation (regulate) of in Kupffer cells Gene_expression (expression) of MCP-1 in monocytes
3) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.72 Pain Relevance 0.21

General Comments

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