INT252842

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ENOPH1, Ddit3) nucleus (ENOPH1, Ddit3) aging (Ddit3)
small molecule metabolic process (ENOPH1) DNA binding (Ddit3) cytosol (ENOPH1)
Anatomy Link Frequency
liver 2
ENOPH1 (Homo sapiens)
Ddit3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 5 31.76 Quite Low
Inflammation 48 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 27 98.78 Very High Very High Very High
Apoptosis 55 97.64 Very High Very High Very High
Alcoholic Liver Diseases 19 95.00 High High
Chronic Hepatitis 4 94.60 High High
Stress 107 92.04 High High
Death 55 90.24 High High
Targeted Disruption 3 84.64 Quite High
Insulin Resistance 2 80.52 Quite High
Diabetes Mellitus 3 73.00 Quite High
Obesity 4 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to HCV, several studies have shown that HCV-related proteins, including either core proteins as well as E1 and E2 proteins of the envelope, are able to induce overexpression of C/EBP homologous protein (CHOP) via the UPR response, ER depletion of calcium, and apoptosis in liver cells (HCV replicon cells) [215,216].
E1 Positive_regulation (induce) of Gene_expression (overexpression) of C/EBP homologous protein in liver associated with apoptosis and hepatitis c virus infection
1) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 2.42 Pain Relevance 0

General Comments

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