INT252858

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) transmembrane transport (Trpa1)
C5 (Rattus norvegicus)
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 38 92.64 High High
Inflammation 32 91.80 High High
agonist 8 90.32 High High
qutenza 2 86.96 High High
Pain 18 86.08 High High
Antinociceptive 12 71.88 Quite High
Bioavailability 4 68.56 Quite High
antagonist 22 58.40 Quite High
Mechanotransduction 2 38.28 Quite Low
TRP channel 2 24.76 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 50 92.64 High High
INFLAMMATION 34 91.80 High High
Hypersensitivity 68 90.76 High High
Pain 22 86.08 High High
Myelodysplastic Syndromes 2 75.24 Quite High
Helminth Infection 2 44.48 Quite Low
Deafness 2 32.20 Quite Low
Inflammatory Pain 22 19.28 Low Low
Nociception 12 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of HC-030031 to block TRPA1 activation was tested in a FLIPR calcium-influx assay using HEK-293 cells stably expressing human TRPA1.
HC-030031 Negative_regulation (block) of Positive_regulation (activation) of TRPA1
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.63 Pain Relevance 0.57
The ability of HC-030031 to block the direct activation of TRPA1 was investigated by examining the potential inhibition of AITC-induced spontaneous hindpaw lifting.
HC-030031 Negative_regulation (block) of Positive_regulation (activation) of TRPA1
2) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.15 Pain Relevance 0.17

General Comments

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