INT25286

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Context Info
Confidence 0.56
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.17
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1RL1) extracellular space (IL1RL1) extracellular region (IL1RL1)
plasma membrane (IL1RL1) intracellular (IL1RL1)
Anatomy Link Frequency
endothelial cells 1
CLC 1
midbrain tegmentum 1
IL1RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 4 100.00 Very High Very High Very High
midbrain 4 98.76 Very High Very High Very High
Osteoarthritis 112 97.88 Very High Very High Very High
Central nervous system 25 95.56 Very High Very High Very High
Cluster headache 5 94.28 High High
cytokine 93 94.08 High High
positron emission tomography 4 91.20 High High
headache 5 89.28 High High
cINOD 3 88.40 High High
Inflammation 127 86.16 High High
Disease Link Frequency Relevance Heat
Viral Meningitis 42 100.00 Very High Very High Very High
Osteoarthritis 114 97.88 Very High Very High Very High
Aspergillus Infection 1 96.60 Very High Very High Very High
Chronic Sinusitis 14 96.48 Very High Very High Very High
Asthma 332 96.20 Very High Very High Very High
Pseudomonas Infection 1 95.32 Very High Very High Very High
Cluster Headache 5 94.28 High High
Trigeminal Autonomic Cephalalgias 4 89.28 High High
INFLAMMATION 140 86.16 High High
Eosinophilic Esophagitis 5 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the human genome, IL1R2, IL1R1, IL1RL2, IL1RL1, IL18R1 and IL18RAP are located in a 470 kb cluster on 2q11.
Localization (located) of IL1RL1
1) Confidence 0.56 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.57 Pain Relevance 0.33
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Localization (presence) of IL1RL1 in CLC associated with asthma and chronic sinusitis
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.59 Pain Relevance 0.13
Three distinct types of ST2 (also known as T1, Fit-1, and DER4) gene products have been cloned; a soluble secreted form (ST2), a transmembrane receptor form (ST2L), and a variant form (ST2V).
Localization (secreted) of ST2V
3) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.16
Moreover and possibly consequently, CBS-113 A inhibits the oxygen burst of stimulated leukocytes and the release of an interleukin 1-like compound from vascular endothelial cells in culture.
Localization (release) of interleukin 1-like in endothelial cells
4) Confidence 0.08 Published 1989 Journal Arzneimittelforschung Section Abstract Doc Link 2514692 Disease Relevance 0 Pain Relevance 0.09
The precise anatomical localization of the deep brain stimulation (DBS) target places it at the midbrain tegmentum rather than the posterior hypothalamus.
Localization (localization) of stimulation in midbrain tegmentum associated with deep brain stimulation and midbrain
5) Confidence 0.03 Published 2010 Journal Curr Pain Headache Rep Section Abstract Doc Link 20425205 Disease Relevance 0.74 Pain Relevance 1.32
For the CB configuration, the metal voltage of the annular counter-electrode was chosen to ensure complete return of the stimulation current.
Localization (return) of stimulation
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2652101 Disease Relevance 0 Pain Relevance 0
In summary, these data show that both serine and metalloproteases secreted by AGE isolate (T1 genotype), exhibit properties to degrade ECM, which may facilitate amoebic invasion of the deeper lying tissues of the CNS.
Localization (secreted) of T1 genotype associated with central nervous system and viral meningitis
7) Confidence 0.01 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.79 Pain Relevance 0.05

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