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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) transport (Trpv1) cytoplasm (Phax)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1) cytosol (Trpv1)
Trpv1 (Mus musculus)
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 99 100.00 Very High Very High Very High
Potency 3 81.20 Quite High
agonist 16 71.36 Quite High
Dopamine 4 67.84 Quite High
Inflammation 28 60.68 Quite High
Pain 72 58.64 Quite High
Face pain 12 50.00 Quite Low
Analgesic 15 37.72 Quite Low
Morphine 12 27.84 Quite Low
Thermal hyperalgesia 3 5.24 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 60.68 Quite High
Nociception 25 60.00 Quite High
Pain 76 58.64 Quite High
Facial Pain 13 50.00 Quite Low
Toxicity 2 48.40 Quite Low
Hyperalgesia 9 24.92 Low Low
Sprains And Strains 46 10.48 Low Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of capsaicin and RTX to TRPV1 involves amino acid residues which have been shown to reside in N- and C-cytosolic and transmembrane domains of the channel [34, 57, 81, 82].
TRPV1 Binding (Binding) of RTX associated with qutenza
1) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.12 Pain Relevance 0.54
Taken together these results confirm that RTX is specific for TRPV1 and that the effects of pharmacological lesion are not the same as genetic removal of TRPV1.
TRPV1 Binding (specific) of RTX
2) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584042 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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