INT252876

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Tacr1) plasma membrane (Prkaca, Tacr1) nucleoplasm (Prkaca)
mitochondrion (Prkaca) Golgi apparatus (Prkaca) protein complex (Prkaca)
Anatomy Link Frequency
neurons 3
Prkaca (Rattus norvegicus)
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal column 62 94.56 High High
Pain 6 93.16 High High
Visceral pain 26 88.80 High High
nMDA receptor 5 85.76 High High
Kinase C 9 78.96 Quite High
antagonist 7 68.80 Quite High
central sensitization 1 63.44 Quite High
Glutamate receptor 4 59.72 Quite High
Spinal cord 22 54.16 Quite High
intrathecal 4 46.04 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 88.80 High High
Nociception 33 73.04 Quite High
Pain 4 20.36 Low Low
Stress 1 11.36 Low Low
INFLAMMATION 4 10.48 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Dyspepsia 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased phosphorylation of CREB through the activated PKA was involved in CGRP-induced NK1 receptor gene expression in spinal neurons [46].
Positive_regulation (activated) of PKA in neurons Regulation (involved) of Gene_expression (expression) of NK1 receptor gene in neurons
1) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.19 Pain Relevance 0.89

General Comments

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