INT252880

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Tacr1) plasma membrane (Prkaca, Tacr1) nucleoplasm (Prkaca)
mitochondrion (Prkaca) Golgi apparatus (Prkaca) protein complex (Prkaca)
Anatomy Link Frequency
neurons 3
Prkaca (Rattus norvegicus)
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal column 62 100.00 Very High Very High Very High
Kinase C 9 90.08 High High
Pain 6 88.44 High High
Visceral pain 26 84.08 Quite High
nMDA receptor 5 81.04 Quite High
Spinal cord 22 65.28 Quite High
antagonist 7 64.08 Quite High
central sensitization 1 58.72 Quite High
Dorsal horn 5 55.20 Quite High
Glutamate receptor 4 55.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 33 84.16 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 84.08 Quite High
Stress 1 22.48 Low Low
INFLAMMATION 4 21.60 Low Low
Pain 4 15.64 Low Low
Inflammatory Pain 1 14.96 Low Low
Neuropathic Pain 1 13.20 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Dyspepsia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also suggests that activation of PKA in PSDC neurons might increase CREB-induced the expression of NK1 receptor and contribute to the sensitization of PSDC neurons (Figure 2).
Positive_regulation (activation) of PKA in neurons Spec (might) Positive_regulation (increase) of Gene_expression (expression) of NK1 receptor in neurons associated with dorsal column
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.21 Pain Relevance 0.92

General Comments

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