INT252944

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
NIH-3T3 1
astrocytes 1
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 36 20.80 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 12 99.84 Very High Very High Very High
Chromosomal Instability 16 99.80 Very High Very High Very High
Cancer 348 99.72 Very High Very High Very High
Targeted Disruption 108 98.36 Very High Very High Very High
Anaplastic Astrocytoma 4 96.84 Very High Very High Very High
Colon Cancer 8 96.76 Very High Very High Very High
Breast Cancer 20 91.72 High High
Aneuploidy 32 88.08 High High
Pituitary Cancer 52 87.40 High High
Metastasis 48 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their studies, they showed that securin is required for chromosomal stability in humans, as knockout cells exhibited a high rate of chromosome loss similar to those observed in naturally occurring cancers.
Positive_regulation (required) of securin associated with targeted disruption, chromosomal instability and cancer
1) Confidence 0.46 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.72 Pain Relevance 0
Heaney et al. [60] showed a 2.4-fold induction of PTTG1 mRNA in NIH-3T3 cells when treated with bFGF.
Positive_regulation (induction) of PTTG1 mRNA in NIH-3T3
2) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.44 Pain Relevance 0
PTTG1 mRNA expression and protein levels were increased in malignant astrocytes when treated with IGF-I or insulin, whereas in rat embryonic astrocytes, PTTG1 expression and protein levels increased only when cells were exposed to IGF-I.
Positive_regulation (increased) of PTTG1 mRNA in astrocytes associated with malignant neoplastic disease
3) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.45 Pain Relevance 0
Proliferating cancer cells and most tumors express high levels of PTTG.
Positive_regulation (levels) of PTTG associated with cancer
4) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Abstract Doc Link PMC2584053 Disease Relevance 0.92 Pain Relevance 0

General Comments

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