INT252952

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Context Info
Confidence 0.91
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2 5.84 Low Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chromosomal Instability 8 87.44 High High
Ovarian Cancer 32 50.00 Quite Low
Aneuploidy 16 27.12 Quite Low
Cancer 174 23.04 Low Low
Colon Cancer 4 10.32 Low Low
Targeted Disruption 54 5.00 Very Low Very Low Very Low
Apoptosis 36 5.00 Very Low Very Low Very Low
Pituitary Cancer 26 5.00 Very Low Very Low Very Low
Metastasis 24 5.00 Very Low Very Low Very Low
Thyroid Neoplasm 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The premature activation of separin is prevented by the binding of securin, which is activated by the degradation of securin by anaphase-promoting complex (APC) during anaphase [33].
Protein_catabolism (degradation) of securin
1) Confidence 0.91 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0 Pain Relevance 0
The fzy-mediated APC/C activity is required for the degradation of securin during the onset of anaphase, while fzr-mediated APC/C activity is essential for the degradation of mitotic cyclins, fzy, and other substrates [38,39].


Protein_catabolism (degradation) of securin
2) Confidence 0.91 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.09 Pain Relevance 0

General Comments

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