INT252961

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.91
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
mast cell 2
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 98.56 Very High Very High Very High
fibrosis 36 98.12 Very High Very High Very High
endometriosis 1 89.48 High High
ischemia 1 59.92 Quite High
psoriasis 1 35.08 Quite Low
metalloproteinase 11 20.32 Low Low
Pain 10 19.76 Low Low
Osteoarthritis 24 15.00 Low Low
Abeta 12 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 35 99.78 Very High Very High Very High
Hypoxia 63 98.66 Very High Very High Very High
INFLAMMATION 71 98.56 Very High Very High Very High
Fibrosis 86 98.12 Very High Very High Very High
Anaplastic Astrocytoma 2 98.08 Very High Very High Very High
Metaplasia 16 97.48 Very High Very High Very High
Cancer 118 91.04 High High
Apoptosis 58 89.52 High High
Endometriosis (extended) 2 89.48 High High
Lung Cancer 11 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our findings, we suggest that tissue metaplasia in arthrofibrosis results from increased inflammatory-associated oxidative stress, leading to an accumulation of mast cells (secreting FGF), driving fibroblast proliferation and creating avascular regions of hypoxia.
Localization (secreting) of FGF in mast cells associated with stress, inflammation, hypoxia and metaplasia
1) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 2.29 Pain Relevance 0.23
Taken together, we suggest that hypoxia-associated oxidative stress initiates mast cell proliferation and FGF secretion, spurring fibroblast proliferation and tissue fibrosis.
Localization (secretion) of FGF in mast cell associated with stress, fibrosis and hypoxia
2) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2940819 Disease Relevance 1.49 Pain Relevance 0.05
Upon Cu++ binding, it regulates the stress-dependant release of FGF-1 and plays a role in angiogenesis in high-grade astrocytic gliomas [139].
Localization (release) of FGF-1 associated with anaplastic astrocytoma and stress
3) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.91 Pain Relevance 0.07
The serum and various growth factors such as PDGF, FGF, EGF, and TGF-?
Localization (serum) of FGF
4) Confidence 0.05 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.22 Pain Relevance 0

General Comments

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