INT252966

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.70
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
pituitary glands 2
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 63.84 Quite High
Pain 4 16.40 Low Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 108 99.96 Very High Very High Very High
Cancer 348 97.72 Very High Very High Very High
Ovarian Cancer 64 96.00 Very High Very High Very High
Pituitary Cancer 52 94.12 High High
Apoptosis 72 87.60 High High
Retinoblastoma 4 85.52 High High
Aneuploidy 32 76.64 Quite High
Chromosomal Instability 16 76.00 Quite High
Benign Prostatic Hypertrophy 16 73.88 Quite High
Malignant Neoplastic Disease 12 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA and protein of PTTG1 expression was significantly reduced by treatment with siRNA.
Negative_regulation (reduced) of Gene_expression (expression) of PTTG1
1) Confidence 0.23 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.92 Pain Relevance 0
These findings were supported by Zhou et al. [51], who showed that human cells treated with DNA-damaging drugs doxorubicin and bleomycin activated p53 and suppressed PTTG1 expressions.
Negative_regulation (suppressed) of Gene_expression (expressions) of PTTG1
2) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.35 Pain Relevance 0
In addition to ID3, Kim et al. [72] also showed that the angiogenic inhibitor TSP-1 is decreased by 2.5-fold in response to PTTG1 overexpression in vitro.
Negative_regulation (decreased) of Gene_expression (overexpression) of PTTG1
3) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.09 Pain Relevance 0
Crossbreeding of Rb (+/-) animals with PTTG1 transgenic animals showed enlarged pituitary glands and a 3.5-fold increase in the frequency of tumors originating from?
Negative_regulation (Crossbreeding) of Gene_expression (animals) of PTTG1 in pituitary glands associated with targeted disruption and cancer
4) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.35 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox