INT252968

Context Info Confidence 0.45 First Reported 2008 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 5.28 Pain Relevance 3.68

nucleoplasm (TAF9) nucleolus (TAF9) nucleus (TAF9) DNA binding (TAF9) kinase activity (TAF9)

Anatomy Link Frequency anterior 2 HeLa 1 TAF9 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 111 100.00 Congenital analgesia 37 100.00 cannabis 735 99.98 Neuropathic pain 8 98.00 imagery 26 93.84 Nicotine 21 87.60 alcohol 51 87.08 sodium channel 27 77.76 Nav1.7 53 69.44 Paroxysmal extreme pain disorder 12 64.04

Disease Link Frequency Relevance Heat Psychosis 183 100.00 Pain 147 100.00 Apoptosis 18 99.08 Injury 15 98.96 Neuropathic Pain 10 98.00 Loss Of Sense Of Smell 9 93.92 Schizophrenia 93 86.76 Bone Fracture 4 86.64 Targeted Disruption 28 86.08 Urological Neuroanatomy 5 84.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the p21WAF1/CIP1 expression levels did not increase significantly in HeLa cells overexpressed with PTTG1, suggesting that PTTG1 can mediate apoptosis both by p21WAF1/CIP1-dependent and independent pathways.

Neg (not) Positive_regulation (increase) of CIP1 in HeLa associated with apoptosis

1) Confidence 0.45 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.85 Pain Relevance 0

In particular CIP is only activated, relative to fixation, by the 3D shape condition and not by the 2D control conditions.

Neg (not) Positive_regulation (activated) of CIP

2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0.08 Pain Relevance 0

This analysis yielded a more restricted activation pattern compared to Figure 2, but nearly all activation sites left were located in the parietal cortex, including a bilateral activation of CIP, AIP and anterior LIP (Figure 7, yellow voxels).

Positive_regulation (activation) of CIP in anterior

3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0

Intriguingly this latter study failed to report activation of CIP in the contrast 3D shape from texture compared to scrambled controls.

Positive_regulation (activation) of CIP

4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0.08

Strongest activation was observed in CIP, with decreasing strength towards the anterior part of the intraparietal sulcus (IPS).

Positive_regulation (activation) of CIP in anterior

5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0.09

At this level activations were also observed in left AIP and CIP (Figure S2).

Positive_regulation (activations) of CIP

6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0 Pain Relevance 0

To date, only a limited number of inactivating mutations in the SCN9A gene have been found, among which the majority were nonsense mutations resulting in CIP.

Positive_regulation (resulting) of CIP associated with congenital analgesia

7) Confidence 0.26 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.66 Pain Relevance 0.93

CIP is caused by mutations in the SCN9A gene encoding for the Na1.7 channel.

Positive_regulation (caused) of CIP associated with congenital analgesia

8) Confidence 0.26 Published 2010 Journal Dermatology (Basel, Switzerland) Section Abstract Doc Link PMC2969160 Disease Relevance 0.82 Pain Relevance 0.73

d) Try to establish any unique characteristics of the group diagnosed as CIP by

Positive_regulation (diagnosed) of CIP

9) Confidence 0.03 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.22 Pain Relevance 0.60

Cannabis induced psychosis (CIP); is it a 'true' diagnosis?

Positive_regulation (induced) of CIP associated with cannabis and psychosis

10) Confidence 0.03 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.80 Pain Relevance 0.32

Comparison between patients diagnosed as cannabis induced psychosis (CIP) and the rest of the LTC user group

Positive_regulation (induced) of CIP associated with cannabis and psychosis

11) Confidence 0.03 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.70 Pain Relevance 0.75

However, since all 13 presently known mutations causing CIP truncate the protein, we verified that the substitution does not cause aberrant splicing.

Positive_regulation (causing) of CIP associated with pain

12) Confidence 0.01 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.15 Pain Relevance 0.19

General Comments

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