INT252969

Context Info Confidence 0.67 First Reported 2008 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 5.22 Pain Relevance 0.32

nucleoplasm (TAF9) nucleolus (TAF9) nucleus (TAF9) DNA binding (TAF9) kinase activity (TAF9)

Anatomy Link Frequency HeLa 2 A549 2 TAF9 (Homo sapiens)

Pain Link Frequency Relevance Heat cannabis 245 99.98 Nicotine 7 87.60 alcohol 17 87.08 Cannabinoid receptor 2 53.96 metalloproteinase 36 33.68 Inflammation 4 32.08 drug abuse 7 22.36 Cannabinoid 11 5.00 Central nervous system 4 5.00 Kinase C 4 5.00

Disease Link Frequency Relevance Heat Psychosis 61 100.00 Cancer 348 99.76 Apoptosis 72 99.08 Aneuploidy 32 98.32 Lung Cancer 16 91.84 Targeted Disruption 108 86.08 Schizophrenia 31 84.48 Mental Disorders 9 79.32 Hyperplasia 20 64.88 Adenoma 8 62.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the p21WAF1/CIP1 expression levels did not increase significantly in HeLa cells overexpressed with PTTG1, suggesting that PTTG1 can mediate apoptosis both by p21WAF1/CIP1-dependent and independent pathways.

Neg (not) Positive_regulation (increase) of Gene_expression (expression) of CIP1 in HeLa associated with apoptosis

1) Confidence 0.67 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.85 Pain Relevance 0

can induce p21WAF1/CIP1 expression [84-86].

Positive_regulation (induce) of Gene_expression (expression) of CIP1

2) Confidence 0.67 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.13 Pain Relevance 0

The overexpression of p21WAF1/CIP1 was shown to cause both G1/S and G2/M arrest and can effectively suppress tumor growth [82,83].

Positive_regulation (overexpression) of Gene_expression (overexpression) of CIP1 associated with cancer

3) Confidence 0.67 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.45 Pain Relevance 0

They observed no change in the levels of expression of p53 and p21WAF1/CIP1 in PTTG1 overexpressed HeLa cells, whereas the p21WAF1/CIP1 was overexpressed by PTTG1 in A549 cells.

Neg (no) Positive_regulation (overexpressed) of Gene_expression (expression) of CIP1 in A549

4) Confidence 0.45 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.98 Pain Relevance 0

Cannabis induced psychosis (CIP); is it a 'true' diagnosis?

Positive_regulation (induced) of Gene_expression (psychosis) of CIP associated with cannabis and psychosis

5) Confidence 0.03 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.80 Pain Relevance 0.32

General Comments

This test has worked.