INT252975

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 31.96
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
A549 7
pituitary 6
thyroid 4
colon 3
HeLa 3
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 35 93.56 High High
Inflammation 35 88.92 High High
metalloproteinase 316 85.04 High High
imagery 37 61.84 Quite High
Kinase C 35 58.88 Quite High
Central nervous system 35 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 211 100.00 Very High Very High Very High
Pituitary Cancer 494 99.92 Very High Very High Very High
Cancer 3067 99.86 Very High Very High Very High
Targeted Disruption 945 99.84 Very High Very High Very High
Apoptosis 636 99.80 Very High Very High Very High
Metastasis 420 99.48 Very High Very High Very High
Ovarian Cancer 560 99.40 Very High Very High Very High
Aneuploidy 280 99.28 Very High Very High Very High
Endometriosis (extended) 35 99.04 Very High Very High Very High
Benign Prostatic Hypertrophy 140 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pei and Melmed [7] showed that overexpression of PTTG1 in mouse NIH3T3 fibroblasts inhibited cell proliferation and induced cell transformation in vitro.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 in fibroblasts
1) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.75 Pain Relevance 0.19
The overexpression of PTTG1 in tumors correlated with a higher degree of tumor recurrence and tumor aggression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 associated with cancer, aggression and recurrence
2) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.65 Pain Relevance 0.07
This also suggests that PTTG1 overexpression in transgenic mice affects early pituitary multipotential cells or may influence neighboring non-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 in pituitary associated with targeted disruption
3) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.55 Pain Relevance 0.04
They showed activation of the lucifierase gene driven by p21WAF1/CIP1 promoter by PTTG1 cDNA, suggesting that the overexpression of PTTG1 in A549 caused p21WAF1/CIP1-mediated apoptosis, which is an event independent of p53-mediated apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 in A549 associated with apoptosis
4) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.77 Pain Relevance 0
We also observed the overexpression of PTTG1 in tissues of ovarian cancer from different patients (Figure. 5).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 associated with ovarian cancer
5) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.18 Pain Relevance 0
The transient or stable expressions of PTTG1 in these cells were found to increase the frequency of aneuploidy.
Positive_regulation (increase) of Gene_expression (expressions) of PTTG1 associated with aneuploidy
6) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.78 Pain Relevance 0.03
They observed translocation of p53 to the nuclei in cells that overexpressed PTTG1.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PTTG1
7) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.36 Pain Relevance 0.10
Overexpression of PTTG1 in cancer cells supports the argument that PTTG1 is actively involved in cell proliferation as the cancer cell has the highest cell proliferation capacity.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PTTG1 associated with cancer
8) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.80 Pain Relevance 0
In their studies, they overexpressed PTTG1 in HeLa and A549 cells and showed inhibition of cell proliferation, colony formation, and thymidine incorporation.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PTTG1 in A549
9) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.05 Pain Relevance 0
On transfection of these cells, their binding partner PBF, and the PTTG1 expression vector, the transactivation of the luciferase gene was increased by 3-fold.
Positive_regulation (increased) of Gene_expression (expression) of PTTG1
10) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.51 Pain Relevance 0.03
Moreover, the expression levels of PTTG1 increased during cell proliferation and in mitosis in a cell cycle-dependent manner, which indicates its role in regulation of the cell cycle [53].
Positive_regulation (increased) of Gene_expression (expression) of PTTG1
11) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.65 Pain Relevance 0
As reported above, PTTG1 is found to be overexpressed in most of the ovarian tumors analyzed to date and the PTTG1 promoter is specifically activated in tumor cells, including OSE tumor cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PTTG1 in OSE associated with cancer and ovarian cancer
12) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.21 Pain Relevance 0
The PTTG1 and PBF expressions were upregulated in thyroid cancer [27,55,56] and were reported to stimulate bFGF expression [11].
Positive_regulation (upregulated) of Gene_expression (expressions) of PTTG1 in thyroid associated with thyroid neoplasm
13) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.41 Pain Relevance 0.03
No significant change in p53 expressions was observed in either cell line transfected with PTTG1.
Positive_regulation (transfected) of Gene_expression (transfected) of PTTG1
14) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.83 Pain Relevance 0
From these experiments, they observed no significant reduction in reporter activity when transfected with NIS basal promoter with PTTG1, but did observe a significant reduction in reporter expressions when transfected with PTTG1 and hNUE as well as its fusion with NIS.
Positive_regulation (transfected) of Gene_expression (transfected) of PTTG1
15) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.34 Pain Relevance 0
These investigators also observed the median survival time (8.5 months) for patients with high PTTG1 expression levels compared to the survival time (14.0 months) for patients with low PTTG1 expression levels, suggesting a role of PTTG1 in metastasis.
Positive_regulation (levels) of Gene_expression (expression) of PTTG1 associated with metastasis
16) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.16 Pain Relevance 0.09
On the other hand, Yu et al. [26] demonstrated predominant nuclear localization of PTTG1 during interphase in JEG-3 cells when transfected with wild type PTTG1, a FLAG epitope-tagged PTTG1, or a PTTG1-EGFP construct.
Positive_regulation (transfected) of Gene_expression (transfected) of PTTG1 in JEG-3
17) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.15 Pain Relevance 0.03
We [18] transfected H1299 cells with PTTG1 siRNA duplex and found that PTTG1 mRNA was almost completely depleted within a day or two in comparison to untransfected or control cells.
Positive_regulation (transfected) of Gene_expression (transfected) of PTTG1
18) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.91 Pain Relevance 0
Increases in pituitary hyperplasia in PTTG1 overexpressing cells were observed in these bitransgenic mice when compared to Rb+/- mice, supporting a role of PTTG1 in pituitary gland tumorigenesis.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PTTG1 in pituitary gland associated with pituitary cancer
19) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.04 Pain Relevance 0
These investigators also observed the median survival time (8.5 months) for patients with high PTTG1 expression levels compared to the survival time (14.0 months) for patients with low PTTG1 expression levels, suggesting a role of PTTG1 in metastasis.
Positive_regulation (role) of Gene_expression (expression) of PTTG1 associated with metastasis
20) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.39 Pain Relevance 0.09

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