INT252977

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 8.39
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
OSE 1
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 93.56 High High
Inflammation 8 19.88 Low Low
metalloproteinase 72 7.68 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 696 99.84 Very High Very High Very High
Metastasis 96 99.84 Very High Very High Very High
Ovarian Cancer 128 99.48 Very High Very High Very High
Breast Cancer 40 99.48 Very High Very High Very High
Pituitary Cancer 104 97.40 Very High Very High Very High
Malignant Neoplastic Disease 24 96.56 Very High Very High Very High
Targeted Disruption 216 95.72 Very High Very High Very High
Pain 8 93.56 High High
Apoptosis 144 89.48 High High
Esophageal Cancer 16 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much has been investigated and is known about the upregulation of PTTG1, downregulation of PTTG of keen interest at this point.
Positive_regulation (upregulation) of PTTG1
1) Confidence 0.28 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.10 Pain Relevance 0
As reported above, PTTG1 is found to be overexpressed in most of the ovarian tumors analyzed to date and the PTTG1 promoter is specifically activated in tumor cells, including OSE tumor cells.
Positive_regulation (activated) of PTTG1 in OSE associated with cancer and ovarian cancer
2) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.23 Pain Relevance 0
The Neighbor phylogenetic tree analyses of human PTTG homologues revealed that PTTG2 and PTTG3 are more similar and formed a cluster leaving PTTG1 separate (Fig. 2).
Positive_regulation (leaving) of PTTG1
3) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.08 Pain Relevance 0
These investigators also observed the median survival time (8.5 months) for patients with high PTTG1 expression levels compared to the survival time (14.0 months) for patients with low PTTG1 expression levels, suggesting a role of PTTG1 in metastasis.
Positive_regulation (levels) of PTTG1 associated with metastasis
4) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.16 Pain Relevance 0.09
These investigators also observed the median survival time (8.5 months) for patients with high PTTG1 expression levels compared to the survival time (14.0 months) for patients with low PTTG1 expression levels, suggesting a role of PTTG1 in metastasis.
Positive_regulation (role) of PTTG1 associated with metastasis
5) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.40 Pain Relevance 0.09
In their experiments, they suggested that the absence of PTTG1 may allow expression of p21, which causes cell cycle arrest.
Positive_regulation (absence) of PTTG1
6) Confidence 0.20 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.89 Pain Relevance 0
PTTG1 has been identified as one of eight signature genes upregulated in human primary tumors that are associated with tumor metastasis [79].
Positive_regulation (upregulated) of PTTG1 associated with cancer and metastasis
7) Confidence 0.19 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.19 Pain Relevance 0
Soon after the isolation and characterization of PTTG1 in humans, Heaney et al. [60] reported that PTTG1 is regulated in vivo and in vitro by estrogen and that its induction levels coincide with bFGF and vascular endothelial growth factor (VEGF).
Positive_regulation (induction) of PTTG1
8) Confidence 0.19 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0

General Comments

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