INT252993

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.93
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
Anatomy Link Frequency
extracellular matrix 3
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 78 99.84 Very High Very High Very High
cytokine 12 97.22 Very High Very High Very High
alcohol 12 84.48 Quite High
anesthesia 12 62.24 Quite High
Spinal cord 1 40.08 Quite Low
Chronic pancreatitis 15 30.48 Quite Low
Inflammation 23 22.32 Low Low
Pain 6 12.56 Low Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 11 99.44 Very High Very High Very High
Cancer 338 99.32 Very High Very High Very High
Asthma 174 98.32 Very High Very High Very High
Pancreatic Cancer 81 98.24 Very High Very High Very High
Stress 26 97.92 Very High Very High Very High
Hypersensitivity 8 94.32 High High
Nicotine Addiction 22 84.00 Quite High
Disease 22 78.52 Quite High
Malignant Neoplastic Disease 8 77.68 Quite High
Liver Cancer 9 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More interestingly, aspirin, as an inhibitor of THBS1, has recently shown to lead to reduction in THBS1 levels [29].
Negative_regulation (inhibitor) of THBS1 associated with aspirin
1) Confidence 0.55 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2896935 Disease Relevance 0.86 Pain Relevance 0.13
More interestingly, aspirin, as an inhibitor of THBS1, has recently shown to lead to reduction in THBS1 levels [29].
Negative_regulation (reduction) of THBS1 associated with aspirin
2) Confidence 0.55 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2896935 Disease Relevance 0.86 Pain Relevance 0.13
As expected, compared to the control (cells transfected with a siRNA vector specifically targeting GFP expression), E2F-1 knockdown could inhibit TSP-1 promoter (?
Negative_regulation (inhibit) of TSP-1 promoter
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Downregulation of THBS1 can cause human cancer and may aid in immune evasion of KSHV infected cells.
Negative_regulation (Downregulation) of THBS1 associated with herpes simplex virus and cancer
4) Confidence 0.40 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.11 Pain Relevance 0
Furthermore, we found that the knockdown of endogenous E2F-1 could inhibit TSP-1 promoter activity significantly, confirming the relevance of E2F-1 mediated regulation of TSP-1 in vivo.
Negative_regulation (inhibit) of TSP-1 promoter
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of THBS1 in extracellular matrix associated with cytokine
6) Confidence 0.35 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.92 Pain Relevance 0.15
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of THBS1 in extracellular matrix associated with cytokine
7) Confidence 0.12 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.92 Pain Relevance 0.15
In addition to ID3, Kim et al. [72] also showed that the angiogenic inhibitor TSP-1 is decreased by 2.5-fold in response to PTTG1 overexpression in vitro.
Negative_regulation (decreased) of TSP-1
8) Confidence 0.03 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.08 Pain Relevance 0
Molecularly, the SPARC protein binds to a number of different extracellular matrix components, such as thrombospondin 1, vitronectin, entactin/nidogen, fibrillar collagens (types I, II, III, and V), and collagen type IV.
Negative_regulation (number) of thrombospondin 1 in extracellular matrix
9) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2862018 Disease Relevance 1.18 Pain Relevance 0.04

General Comments

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