INT252999

Context Info Confidence 0.75 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 12.65 Pain Relevance 2.92

nucleoplasm (TAF9) nucleolus (TAF9) nucleus (TAF9) DNA binding (TAF9) kinase activity (TAF9)

Anatomy Link Frequency A549 2 HeLa 1 TAF9 (Homo sapiens)

Pain Link Frequency Relevance Heat Congenital analgesia 17 100.00 Visceral pain 1 99.92 cannabis 1225 99.82 Pain 39 98.96 withdrawal 10 95.64 alcohol 85 95.20 depression 5 94.32 Nicotine 35 87.28 Paroxysmal extreme pain disorder 6 81.68 Central nervous system 7 56.92

Disease Link Frequency Relevance Heat Psychosis 305 100.00 Pain 56 100.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 1 99.92 Cancer 522 99.76 Apoptosis 108 99.08 Aneuploidy 48 98.32 Alcohol Addiction 5 95.64 Depression 5 94.32 Recurrence 26 93.52 Manic Depressive Disorder 10 93.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the p21WAF1/CIP1 expression levels did not increase significantly in HeLa cells overexpressed with PTTG1, suggesting that PTTG1 can mediate apoptosis both by p21WAF1/CIP1-dependent and independent pathways.

Gene_expression (expression) of CIP1 in HeLa associated with apoptosis

1) Confidence 0.75 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.83 Pain Relevance 0

can induce p21WAF1/CIP1 expression [84-86].

Gene_expression (expression) of CIP1

2) Confidence 0.75 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.13 Pain Relevance 0

They observed no change in the levels of expression of p53 and p21WAF1/CIP1 in PTTG1 overexpressed HeLa cells, whereas the p21WAF1/CIP1 was overexpressed by PTTG1 in A549 cells.

Gene_expression (overexpressed) of CIP1 in A549

3) Confidence 0.75 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.90 Pain Relevance 0

The overexpression of p21WAF1/CIP1 was shown to cause both G1/S and G2/M arrest and can effectively suppress tumor growth [82,83].

Gene_expression (overexpression) of CIP1 associated with cancer

4) Confidence 0.75 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.45 Pain Relevance 0

These investigators also studied the effect of PTTG1 on p21WAF1/CIP1 expression by the luciferase assay.

Gene_expression (expression) of CIP1

5) Confidence 0.75 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.83 Pain Relevance 0

They observed no change in the levels of expression of p53 and p21WAF1/CIP1 in PTTG1 overexpressed HeLa cells, whereas the p21WAF1/CIP1 was overexpressed by PTTG1 in A549 cells.

Gene_expression (expression) of CIP1 in A549

6) Confidence 0.58 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.98 Pain Relevance 0

CIP presents immediately after birth and is characterized mainly by insensitivity to pain which is the common feature among all affected individuals, although clinical heterogeneity exists, as some patients develop anosmia while others have intact smell sensation.

Gene_expression (presents) of CIP associated with pain, congenital analgesia and loss of sense of smell

7) Confidence 0.37 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.37 Pain Relevance 1.06

Cannabis induced psychosis (CIP); is it a 'true' diagnosis?

Gene_expression (psychosis) of CIP associated with cannabis and psychosis

8) Confidence 0.05 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.80 Pain Relevance 0.32

Clinic records also showed that 17(16.5%) patients (10 of them in their first presentation) were diagnosed as CIP.

Gene_expression (diagnosed) of CIP associated with psychosis

9) Confidence 0.05 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 0.80 Pain Relevance 0.59

Yet, we could not elicit any significant difference between those having a presentation of CIP and others (or CIP-SSD patients and other LTC user SSD patients) regarding age and positive symptoms.

Gene_expression (presentation) of CIP associated with cannabis and psychosis

10) Confidence 0.05 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 1.20 Pain Relevance 0.40

This section compares the 7 patients diagnosed with SSD after having an initial diagnosis of CIP with other SSD patients in the LTC user group.

Gene_expression (diagnosis) of CIP associated with cannabis and psychosis

11) Confidence 0.05 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 1.15 Pain Relevance 0.31

Comparison between SSD patients in CIP group (CIP-SSD) and other LTC user SSD patients

Gene_expression (group) of CIP associated with cannabis and psychosis

12) Confidence 0.05 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2910013 Disease Relevance 1.11 Pain Relevance 0.25

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