INT253

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 38
Speculated 8
Reported most in Abstract
Documents 184
Total Number 192
Disease Relevance 47.27
Pain Relevance 65.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 21
thyroid 8
pituitary 8
blood 6
follicle 4
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 580 100.00 Very High Very High Very High
agonist 545 100.00 Very High Very High Very High
narcan 273 100.00 Very High Very High Very High
Morphine 139 100.00 Very High Very High Very High
Endogenous opioid 96 100.00 Very High Very High Very High
Clonidine 85 100.00 Very High Very High Very High
Pain 69 100.00 Very High Very High Very High
anesthesia 62 100.00 Very High Very High Very High
tricyclic antidepressant 57 100.00 Very High Very High Very High
Enkephalin 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 132 100.00 Very High Very High Very High
Pain 40 100.00 Very High Very High Very High
Rheumatoid Arthritis 4 100.00 Very High Very High Very High
Cancer 163 99.84 Very High Very High Very High
INFLAMMATION 69 99.68 Very High Very High Very High
Hypoglycemia 25 99.52 Very High Very High Very High
Ganglion Cysts 7 99.52 Very High Very High Very High
Epilepsy 19 99.48 Very High Very High Very High
Phobia 8 99.42 Very High Very High Very High
Hypertension 114 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential responses in prolactin levels induced by naloxone in humans.
Regulation (responses) of prolactin associated with narcan
1) Confidence 0.62 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 4034850 Disease Relevance 0.24 Pain Relevance 0.58
PRL levels in all pregnant patients at term were unaffected by the administration of synthetic narcotic analgesic agents, anesthesia, or the stress of operation.
Neg (unaffected) Regulation (unaffected) of PRL associated with stress, anesthesia and analgesic
2) Confidence 0.62 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0.10 Pain Relevance 0.20
Role of opiates in the physiological control of prolactin in man.
Regulation (control) of prolactin associated with enkephalin and opiate
3) Confidence 0.62 Published 1983 Journal Acta Eur. Fertil. Section Title Doc Link 6326452 Disease Relevance 0.28 Pain Relevance 0.58
Effect of piperoxane on serum prolactin: possible role of epinephrine-mediated synapses in the inhibition of prolactin secretion.
Regulation (Effect) of prolactin in synapses
4) Confidence 0.62 Published 1978 Journal Endocrinology Section Title Doc Link 217617 Disease Relevance 0 Pain Relevance 0.21
The iv administration of 5 mg/kg piperoxane also produced a rapid and significant increase, whereas saline 0.5 mg/kg or 1.0 mg/kg, did not change serum PRL levels.
Neg (not) Regulation (change) of PRL
5) Confidence 0.62 Published 1978 Journal Endocrinology Section Abstract Doc Link 217617 Disease Relevance 0 Pain Relevance 0.26
One half of the women were given bromocriptine to control PRL levels during anesthesia.
Regulation (control) of PRL associated with anesthesia
6) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.09 Pain Relevance 0.43
To define changes in peripheral plasma progesterone (P) and prolactin (PRL) levels in relation to oocyte recovery for in vitro fertilization (IVF), the authors studied these hormones in 20 women before, during, and after oocyte recovery for IVF.
Regulation (changes) of prolactin in oocyte
7) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.31
Changes in PRL levels and P levels during oocyte retrieval were not related to the occurrence of pregnancy.
Regulation (Changes) of PRL in oocyte
8) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.37
To define changes in peripheral plasma progesterone (P) and prolactin (PRL) levels in relation to oocyte recovery for in vitro fertilization (IVF), the authors studied these hormones in 20 women before, during, and after oocyte recovery for IVF.
Regulation (changes) of PRL in oocyte
9) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.31
A 3-day course of fluoxetine (30 mg daily) had no demonstrable effect on fasting PRL levels.
Neg (no) Regulation (effect) of PRL associated with fluoxetine
10) Confidence 0.62 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 313936 Disease Relevance 0 Pain Relevance 0.41
He was then successfully treated with clonidine, an antinoradrenergic compound without antidopaminergic properties, which had no effect on serum prolactin or tumor growth.
Neg (no) Regulation (effect) of prolactin associated with cancer and clonidine
11) Confidence 0.62 Published 1985 Journal Gen Hosp Psychiatry Section Abstract Doc Link 4065553 Disease Relevance 0.53 Pain Relevance 0.10
Controversial data are available on the effect of chemotherapy and immunosuppression on prolactin levels.
Regulation (effect) of prolactin
12) Confidence 0.62 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.42 Pain Relevance 0.09
Age-related differences in the serum prolactin response during standardized surgery.
Regulation (response) of prolactin associated with anesthesia
13) Confidence 0.62 Published 1984 Journal Life Sci. Section Title Doc Link 6513733 Disease Relevance 0.18 Pain Relevance 0.18
Serum prolactin levels were unaffected by anesthesia with pentobarbital sodium (15 mg/kg b.w., i.v.).
Neg (unaffected) Regulation (unaffected) of Serum prolactin associated with anesthesia
14) Confidence 0.62 Published 1992 Journal Lab. Anim. Sci. Section Abstract Doc Link 1320162 Disease Relevance 0 Pain Relevance 0.19
The effect of PGE2 or PG synthesis inhibitors on gonadotrophin and prolactin (PRL) levels was evaluated in 50 volunteers (25 males and 25 females).
Regulation (effect) of PRL
15) Confidence 0.62 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.23
The effect of PGE2 or PG synthesis inhibitors on gonadotrophin and prolactin (PRL) levels was evaluated in 50 volunteers (25 males and 25 females).
Regulation (effect) of prolactin
16) Confidence 0.62 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.23
The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.
Spec (investigate) Regulation (effects) of PRL in plasma associated with anesthesia
17) Confidence 0.61 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0 Pain Relevance 0.17
The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.
Spec (investigate) Regulation (effects) of prolactin in plasma associated with anesthesia
18) Confidence 0.61 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0 Pain Relevance 0.17
To evaluate the possible involvement of endogenous opioid peptides in the responses of PRL, LH, and cortisol to surgical stress, we have studied the effect of naloxone on these hormones in otherwise normal subjects of both sexes undergoing cholecystectomy for gallstones.
Spec (possible) Regulation (responses) of PRL associated with stress, narcan, endogenous opioid and gallstones
19) Confidence 0.61 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7085859 Disease Relevance 0.27 Pain Relevance 0.35
Effect of diclofenac on plasma levels of immunoreactive prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropin, and beta-endorphin in humans.
Regulation (Effect) of prolactin in follicle associated with diclofenac
20) Confidence 0.60 Published 1988 Journal Horm. Res. Section Title Doc Link 2975630 Disease Relevance 0.09 Pain Relevance 0.28

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