INT253

Context Info Confidence 0.62 First Reported 1975 Last Reported 2010 Negated 38 Speculated 8 Reported most in Abstract Documents 184 Total Number 192 Disease Relevance 47.27 Pain Relevance 65.79

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)

Anatomy Link Frequency plasma 21 thyroid 8 pituitary 8 blood 6 follicle 4 PRL (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 580 100.00 agonist 545 100.00 narcan 273 100.00 Morphine 139 100.00 Endogenous opioid 96 100.00 Clonidine 85 100.00 Pain 69 100.00 anesthesia 62 100.00 tricyclic antidepressant 57 100.00 Enkephalin 32 100.00

Disease Link Frequency Relevance Heat Stress 132 100.00 Pain 40 100.00 Rheumatoid Arthritis 4 100.00 Cancer 163 99.84 INFLAMMATION 69 99.68 Hypoglycemia 25 99.52 Ganglion Cysts 7 99.52 Epilepsy 19 99.48 Phobia 8 99.42 Hypertension 114 99.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Differential responses in prolactin levels induced by naloxone in humans.

Regulation (responses) of prolactin associated with narcan

1) Confidence 0.62 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 4034850 Disease Relevance 0.24 Pain Relevance 0.58

PRL levels in all pregnant patients at term were unaffected by the administration of synthetic narcotic analgesic agents, anesthesia, or the stress of operation.

Neg (unaffected) Regulation (unaffected) of PRL associated with stress, anesthesia and analgesic

2) Confidence 0.62 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0.10 Pain Relevance 0.20

Role of opiates in the physiological control of prolactin in man.

Regulation (control) of prolactin associated with enkephalin and opiate

3) Confidence 0.62 Published 1983 Journal Acta Eur. Fertil. Section Title Doc Link 6326452 Disease Relevance 0.28 Pain Relevance 0.58

Effect of piperoxane on serum prolactin: possible role of epinephrine-mediated synapses in the inhibition of prolactin secretion.

Regulation (Effect) of prolactin in synapses

4) Confidence 0.62 Published 1978 Journal Endocrinology Section Title Doc Link 217617 Disease Relevance 0 Pain Relevance 0.21

The iv administration of 5 mg/kg piperoxane also produced a rapid and significant increase, whereas saline 0.5 mg/kg or 1.0 mg/kg, did not change serum PRL levels.

Neg (not) Regulation (change) of PRL

5) Confidence 0.62 Published 1978 Journal Endocrinology Section Abstract Doc Link 217617 Disease Relevance 0 Pain Relevance 0.26

One half of the women were given bromocriptine to control PRL levels during anesthesia.

Regulation (control) of PRL associated with anesthesia

6) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.09 Pain Relevance 0.43

To define changes in peripheral plasma progesterone (P) and prolactin (PRL) levels in relation to oocyte recovery for in vitro fertilization (IVF), the authors studied these hormones in 20 women before, during, and after oocyte recovery for IVF.

Regulation (changes) of prolactin in oocyte

7) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.31

Changes in PRL levels and P levels during oocyte retrieval were not related to the occurrence of pregnancy.

Regulation (Changes) of PRL in oocyte

8) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.37

To define changes in peripheral plasma progesterone (P) and prolactin (PRL) levels in relation to oocyte recovery for in vitro fertilization (IVF), the authors studied these hormones in 20 women before, during, and after oocyte recovery for IVF.

Regulation (changes) of PRL in oocyte

9) Confidence 0.62 Published 1986 Journal Fertil. Steril. Section Abstract Doc Link 2938986 Disease Relevance 0.08 Pain Relevance 0.31

A 3-day course of fluoxetine (30 mg daily) had no demonstrable effect on fasting PRL levels.

Neg (no) Regulation (effect) of PRL associated with fluoxetine

10) Confidence 0.62 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 313936 Disease Relevance 0 Pain Relevance 0.41

He was then successfully treated with clonidine, an antinoradrenergic compound without antidopaminergic properties, which had no effect on serum prolactin or tumor growth.

Neg (no) Regulation (effect) of prolactin associated with cancer and clonidine

11) Confidence 0.62 Published 1985 Journal Gen Hosp Psychiatry Section Abstract Doc Link 4065553 Disease Relevance 0.53 Pain Relevance 0.10

Controversial data are available on the effect of chemotherapy and immunosuppression on prolactin levels.

Regulation (effect) of prolactin

12) Confidence 0.62 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.42 Pain Relevance 0.09

Age-related differences in the serum prolactin response during standardized surgery.

Regulation (response) of prolactin associated with anesthesia

13) Confidence 0.62 Published 1984 Journal Life Sci. Section Title Doc Link 6513733 Disease Relevance 0.18 Pain Relevance 0.18

Serum prolactin levels were unaffected by anesthesia with pentobarbital sodium (15 mg/kg b.w., i.v.).

Neg (unaffected) Regulation (unaffected) of Serum prolactin associated with anesthesia

14) Confidence 0.62 Published 1992 Journal Lab. Anim. Sci. Section Abstract Doc Link 1320162 Disease Relevance 0 Pain Relevance 0.19

The effect of PGE2 or PG synthesis inhibitors on gonadotrophin and prolactin (PRL) levels was evaluated in 50 volunteers (25 males and 25 females).

Regulation (effect) of PRL

15) Confidence 0.62 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.23

The effect of PGE2 or PG synthesis inhibitors on gonadotrophin and prolactin (PRL) levels was evaluated in 50 volunteers (25 males and 25 females).

Regulation (effect) of prolactin

16) Confidence 0.62 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.23

The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.

Spec (investigate) Regulation (effects) of PRL in plasma associated with anesthesia

17) Confidence 0.61 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0 Pain Relevance 0.17

The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.

Spec (investigate) Regulation (effects) of prolactin in plasma associated with anesthesia

18) Confidence 0.61 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0 Pain Relevance 0.17

To evaluate the possible involvement of endogenous opioid peptides in the responses of PRL, LH, and cortisol to surgical stress, we have studied the effect of naloxone on these hormones in otherwise normal subjects of both sexes undergoing cholecystectomy for gallstones.

Spec (possible) Regulation (responses) of PRL associated with stress, narcan, endogenous opioid and gallstones

19) Confidence 0.61 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7085859 Disease Relevance 0.27 Pain Relevance 0.35

Effect of diclofenac on plasma levels of immunoreactive prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropin, and beta-endorphin in humans.

Regulation (Effect) of prolactin in follicle associated with diclofenac

20) Confidence 0.60 Published 1988 Journal Horm. Res. Section Title Doc Link 2975630 Disease Relevance 0.09 Pain Relevance 0.28

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