INT253008

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTTG1, Id3) nucleus (PTTG1, Id3) chromosome segregation (PTTG1)
cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
Anatomy Link Frequency
SH3 2
PTTG1 (Homo sapiens)
Id3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 18 71.12 Quite High
Ovarian Cancer 48 50.00 Quite Low
Cancer 261 33.76 Quite Low
Colon Cancer 6 17.56 Low Low
Liver Cancer 9 16.44 Low Low
Uterine Fibroids 3 15.68 Low Low
Breast Cancer 15 14.56 Low Low
Testicular Cancer 3 13.04 Low Low
Lung Cancer 12 11.84 Low Low
Esophageal Cancer 6 8.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, these investigators suggest that the mechanisms by which PTTG1 regulates TSP-1 and ID3 expression may be direct or indirect, but it remains unclear along which pathway PTTG1 exerts this effect.
PTTG1 Regulation (regulates) of Gene_expression (expression) of ID3
1) Confidence 0.03 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.07 Pain Relevance 0
Furthermore, these investigators showed that the effects of PTTG1 on ID3 expression were significantly reduced when they used the SH3 domain mutant of PTTG1, suggesting an important role for the SH3 domain in regulating ID3 expression.
PTTG1 Regulation (effects) of Gene_expression (expression) of ID3 in SH3
2) Confidence 0.03 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.06 Pain Relevance 0
The mechanisms by which PTTG1 regulates expression of TSP-1 and ID3 are not clear.
PTTG1 Regulation (regulates) of Gene_expression (expression) of ID3
3) Confidence 0.03 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.07 Pain Relevance 0

General Comments

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