INT253018

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PTTG1, Zic2) cell differentiation (Zic2) chromosome segregation (PTTG1)
DNA binding (Zic2) cytoplasm (PTTG1) cytosol (PTTG1)
Anatomy Link Frequency
terminal portion 1
PTTG1 (Homo sapiens)
Zic2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 9 87.92 High High
Aneuploidy 24 84.36 Quite High
Chromosomal Instability 12 83.72 Quite High
Apoptosis 54 72.16 Quite High
Cancer 261 66.08 Quite High
Targeted Disruption 81 54.68 Quite High
Anaplastic Astrocytoma 3 50.24 Quite High
Ovarian Cancer 48 50.00 Quite Low
Colon Cancer 6 48.72 Quite Low
Thyroid Neoplasm 18 47.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Romero et al. [50] showed that the Ku dimer interacts with the N-terminal portion of human PTTG1.
PTTG1 Binding (interacts) of Ku in terminal portion
1) Confidence 0.01 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.27 Pain Relevance 0
In their experiment, they isolated a protein of 70 kDa, Ku-70, which specifically interacts with PTTG1.
PTTG1 Binding (interacts) of Ku
2) Confidence 0.01 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.09 Pain Relevance 0
The occurrence of genome damaging events such as double-strand breakage can disrupt the association of PTTG1 with Ku-70 [50].
PTTG1 Binding (association) of Ku
3) Confidence 0.01 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.41 Pain Relevance 0

General Comments

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