INT253022

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PTTG1, Trp53) cytoplasm (PTTG1, Trp53) cytosol (PTTG1, Trp53)
chromosome organization (PTTG1, Trp53) nucleoplasm (Trp53) mitochondrion (Trp53)
PTTG1 (Homo sapiens)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 87 100.00 Very High Very High Very High
Hepatocellular Cancer 4 99.84 Very High Very High Very High
Liver Cancer 3 96.88 Very High Very High Very High
Herpes Simplex Virus 1 67.36 Quite High
Ovarian Cancer 16 66.64 Quite High
Cystitis 1 53.52 Quite High
Conjunctivitis 1 53.12 Quite High
Gastroenteritis 1 52.48 Quite High
Common Cold 1 51.80 Quite High
Targeted Disruption 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their experiment, they showed that PTTG1 serves as a negative regulator of p53 tumor suppression in hepatocellular carcinoma (HCC) and that depletion of PTTG1 significantly inhibits growth of PTTG1-overexpressing HCC cell lines in vitro and in vivo.
PTTG1 Negative_regulation (regulator) of Negative_regulation (suppression) of p53 associated with cancer and hepatocellular cancer
1) Confidence 0.03 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0

General Comments

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