INT25307

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 1
fibroblasts 1
Igkv1-35 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 83.68 Quite High
Inflammation 4 68.80 Quite High
Analgesic 2 63.76 Quite High
aspirin 2 60.96 Quite High
Disease Link Frequency Relevance Heat
Contracture 21 100.00 Very High Very High Very High
INFLAMMATION 4 68.80 Quite High
Disease 4 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vitro antioxidant activity, evaluated in human epithelial or transformed neoplastic keratinocyte cells, HaCaT, and normal dermal fibroblasts in terms of cell survival following ultraviolet B (UVB) irradiation, was significantly increased in the presence of Cu2(asp)4, Cu(sal)2, and CuSO4.
Gene_expression (presence) of Cu2 in fibroblasts
1) Confidence 0.64 Published 2005 Journal J. Biol. Inorg. Chem. Section Abstract Doc Link 16261369 Disease Relevance 0.19 Pain Relevance 0.16
Further, ROS generation following UVA irradiation in the skin of hairless mice following oral treatment with Cu2(asp)4 for three consecutive days was significantly suppressed compared to the vehicle- or Cu(ace)2-treated mice.
Gene_expression (generation) of Cu2 in skin
2) Confidence 0.50 Published 2005 Journal J. Biol. Inorg. Chem. Section Abstract Doc Link 16261369 Disease Relevance 0.18 Pain Relevance 0.16
Both Cu2+- and caffeine-contractures were produced rapidly and relaxed spontaneously; the selenite-contracture occurred after a latent period of about 45 min and lasted for more than 3 hr.
Gene_expression (produced) of Cu2 associated with contracture
3) Confidence 0.47 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2515819 Disease Relevance 0.72 Pain Relevance 0.08

General Comments

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