INT253079

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prok2, Il10) cell proliferation (Prok2) extracellular space (Il10)
intracellular (Il10)
Prok2 (Mus musculus)
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 84 88.96 High High
agonist 6 50.00 Quite Low
Inflammation 24 48.88 Quite Low
addiction 2 6.12 Low Low
IPN 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 20 90.80 High High
INFLAMMATION 26 48.88 Quite Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Hematological Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Immune System Diseases 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is confirmed by our in vitro experiments showing that Bv8 also decreases IL-10 and IL-4 levels when added to splenocytes at the time of antigen restimulation.
Bv8 Negative_regulation (decreases) of IL-10
1) Confidence 0.24 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.08 Pain Relevance 0.10
In order to assess the type of PROK receptor involved in the Bv8-induced decrease in IL-10 levels, PROKR 1 KO mice were immunised with KLH and treated in vivo with Bv8 at the same time (Fig. 8, panel A) or two weeks later, four hours before the collection of splenocytes (Fig. 8, panel B).
Bv8 Negative_regulation (decrease) of IL-10
2) Confidence 0.21 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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