INT253098

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
Anatomy Link Frequency
macrophages 2
muscle tissue 2
muscle 2
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
cytokine 34 99.84 Very High Very High Very High
agonist 20 88.24 High High
Inflammation 8 86.16 High High
tolerance 18 14.64 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.98 Very High Very High Very High
Insulin Resistance 87 99.04 Very High Very High Very High
Obesity 51 98.12 Very High Very High Very High
Diabetes Mellitus 34 97.76 Very High Very High Very High
INFLAMMATION 8 86.16 High High
Hyperinsulinism 5 83.04 Quite High
Disorder Of Lipid Metabolism 11 28.16 Quite Low
Body Weight 8 25.68 Quite Low
Impaired Glucose Tolerance 12 14.64 Low Low
Hyperglycemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, transgenic overexpression of PTP1B in muscle decreased glucose uptake (29); meanwhile, ablation of PTP1B specifically in this tissue improved systemic insulin sensitivity when on a high-fat diet (30).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTP1B in muscle associated with targeted disruption
1) Confidence 0.65 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.04 Pain Relevance 0.15
The overexpression of PTP1B in muscle tissue results in insulin resistance [29].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTP1B in muscle tissue associated with insulin resistance
2) Confidence 0.50 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.42 Pain Relevance 0
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Positive_regulation (induced) of Gene_expression (expression) of ptp1b in macrophages associated with metalloproteinase and cytokine
3) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.59 Pain Relevance 0.33

General Comments

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