INT2531

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Context Info
Confidence 0.00
First Reported 1979
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 166
Total Number 168
Disease Relevance 43.08
Pain Relevance 38.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cebpz)
Anatomy Link Frequency
blood 22
myocardium 8
brain 7
nerves 6
neural 5
Cebpz (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 207 100.00 Very High Very High Very High
isoflurane 166 99.98 Very High Very High Very High
anesthesia 248 99.92 Very High Very High Very High
qutenza 45 99.84 Very High Very High Very High
Thalamus 36 99.84 Very High Very High Very High
adenocard 33 99.84 Very High Very High Very High
Morphine 30 99.84 Very High Very High Very High
cva 60 99.80 Very High Very High Very High
narcan 58 99.74 Very High Very High Very High
halothane 113 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 142 100.00 Very High Very High Very High
Fistula 3 100.00 Very High Very High Very High
Hypoxia 92 99.98 Very High Very High Very High
Hypercapnia 34 99.98 Very High Very High Very High
Sepsis 30 99.98 Very High Very High Very High
Sleep Disorders 28 99.98 Very High Very High Very High
Myocardial Stunning 380 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 36 99.82 Very High Very High Very High
Cv General 3 Under Development 24 99.80 Very High Very High Very High
Hypoglycemia 8 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased rCBF of thalamus and precuneus under both conditions in the PR group and decreased rCBF of ACG under post SCS conditions in the GR group were characteristic patterns.
Positive_regulation (Increased) of rCBF in thalamus
1) Confidence 0.00 Published 2006 Journal Ann Nucl Med Section Body Doc Link 16856574 Disease Relevance 0 Pain Relevance 0
RESULTS: (1) In the PR group, increased rCBF was observed in left thalamus, bilateral precuneus and bilateral cerebellum under the baseline condition.
Positive_regulation (increased) of rCBF in cerebellum
2) Confidence 0.00 Published 2006 Journal Ann Nucl Med Section Body Doc Link 16856574 Disease Relevance 0 Pain Relevance 0
We have previously shown activation of CBF in the cortex contralateral to a focal contusion, 24 h after the event.
Positive_regulation (activation) of CBF in cortex associated with contusions
3) Confidence 0.70 Published 2007 Journal Brain Res. Section Abstract Doc Link 17275796 Disease Relevance 0.36 Pain Relevance 0.11
Moreover, an increase of 69% (mean) in CBF was detected after i.v. acetazolamide administration.
Positive_regulation (increase) of CBF
4) Confidence 0.69 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7492995 Disease Relevance 0 Pain Relevance 0.34
Using this approach, parallel increases in neuronal activity and CBF were observed during SWD in the whisker somatosensory (barrel) cortex, whereas the visual cortex showed no significant changes.
Positive_regulation (increases) of CBF in whisker
5) Confidence 0.61 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15356426 Disease Relevance 0.49 Pain Relevance 0.22
Microinjection of L-glutamate (50-100 nmol) into the septal complex also produced an increase in Hpc CBF.
Positive_regulation (increase) of CBF associated with glutamate
6) Confidence 0.61 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2575724 Disease Relevance 0 Pain Relevance 0.22
Electrical stimulation of the septal complex produced a current-dependent increase in Hpc CBF that was accompanied by an increase in extracellular acetylcholine (ACh) release in the hippocampus.
Positive_regulation (increase) of CBF in hippocampus associated with hippocampus
7) Confidence 0.61 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2575724 Disease Relevance 0 Pain Relevance 0.20
A comparison of the results with previous data obtained in conscious rats (Sakurada et al. 1978) demonstrates that 75% N2O moderately reduces local CBF in some, but not all, cortical and subcortical areas, that phenobarbital anesthesia reduces local CBF to between 30 and 65% of (conscious) control, and that pronounced hypoxia (arterial P02 about 25 mmHg) increases local CBF 3- to 4-fold.
Positive_regulation (increases) of CBF associated with anesthesia and hypoxia
8) Confidence 0.61 Published 1979 Journal Acta Physiol. Scand. Section Abstract Doc Link 463579 Disease Relevance 0.26 Pain Relevance 0.34
During neural activation, brain tissue partial pressure of oxygen (P(O2)) and local cerebral blood flow (CBF) were similarly increased.
Positive_regulation (increased) of CBF in blood
9) Confidence 0.60 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19227484 Disease Relevance 0.09 Pain Relevance 0.09
Under normal physiological conditions, increased CBF is associated with improved cerebral oxygenation.
Positive_regulation (increased) of CBF
10) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0.08 Pain Relevance 0
We tested the hypothesis that phosphodiesterase (PDE)-5 blockers, specifically sildenafil and tadalafil, increase CBF in HBO(2) and accelerate seizure development.
Positive_regulation (increase) of CBF associated with convulsion
11) Confidence 0.55 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19179645 Disease Relevance 0.58 Pain Relevance 0.03
Oxygen is a potent cerebral vasoconstrictor, but excessive exposure to hyperbaric oxygen (HBO(2)) can reverse this vasoconstriction by stimulating brain nitric oxide (NO) production, which increases cerebral blood flow (CBF)-a predictor of O(2) convulsions.
Positive_regulation (increases) of CBF in blood associated with convulsion and increased venous pressure under development
12) Confidence 0.55 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19179645 Disease Relevance 0.51 Pain Relevance 0
These data are in contrast to studies in dogs, where sufentanil produced non-dose-dependent increases in CBF and ICP.
Positive_regulation (increases) of CBF associated with cva
13) Confidence 0.51 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1346953 Disease Relevance 0.49 Pain Relevance 0.26
The increase in CBF caused by hemodilution with PFC emulsion has long been recognized; the mechanisms by which PFC emulsions increase CBF are probably multifactorial.
Positive_regulation (increase) of CBF
14) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0.25 Pain Relevance 0.07
Results of animal studies suggest that PFC administration decreases cerebrovascular resistance and blood viscosity, thereby increasing CBF [8], [9].
Positive_regulation (increasing) of CBF in blood
15) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0 Pain Relevance 0
The increase in CBF caused by hemodilution with PFC emulsion has long been recognized; the mechanisms by which PFC emulsions increase CBF are probably multifactorial.
Positive_regulation (increase) of CBF
16) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0.26 Pain Relevance 0.04
In most cases, increased CBF reflects increased metabolic demand or decreased arterial oxygen content (CaO2), and may indicate a need to increase cerebral oxygen delivery.
Positive_regulation (increased) of CBF
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0 Pain Relevance 0
It is well known that hemodilution, characterized by decreased hematocrit (Hct), lowered circulating oxygen content (CaO2), and decreased blood viscosity can increase CBF [3]–[7].
Positive_regulation (increase) of CBF in blood
18) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0 Pain Relevance 0
Findings from animal studies have suggested that the increased CBF and improved oxygenation may be beneficial for patients with ischemic and traumatic brain injury [13]–[16].
Positive_regulation (increased) of CBF in brain associated with brain injury
19) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0.10 Pain Relevance 0
These data, therefore, do not support the contention that isoflurane causes maldistribution of CBF during focal ischemia.
Positive_regulation (causes) of CBF associated with ischemia and isoflurane
20) Confidence 0.50 Published 1989 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815277 Disease Relevance 0.25 Pain Relevance 0.54

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