INT253103

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.56
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
Anatomy Link Frequency
macrophages 2
muscle 2
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 68 100.00 Very High Very High Very High
metalloproteinase 4 100.00 Very High Very High Very High
agonist 40 94.64 High High
Inflammation 16 88.40 High High
tolerance 24 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.98 Very High Very High Very High
Diabetes Mellitus 24 97.76 Very High Very High Very High
Obesity 80 97.24 Very High Very High Very High
Insulin Resistance 160 93.60 High High
INFLAMMATION 16 88.40 High High
Hyperinsulinism 8 84.64 Quite High
Impaired Glucose Tolerance 12 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Negative_regulation (downregulation) of Gene_expression (expression) of ptp1b
1) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.41 Pain Relevance 0.26
However, IL-6 effects on PTP1B expression and activity were completely prevented by treatment with GW3965 or SP600125.


Negative_regulation (prevented) of Gene_expression (expression) of PTP1B
2) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.51 Pain Relevance 0.04
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Negative_regulation (repressed) of Gene_expression (expression) of ptp1b in macrophages associated with metalloproteinase and cytokine
3) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.60 Pain Relevance 0.33
In this regard, transgenic overexpression of PTP1B in muscle decreased glucose uptake (29); meanwhile, ablation of PTP1B specifically in this tissue improved systemic insulin sensitivity when on a high-fat diet (30).
Negative_regulation (decreased) of Gene_expression (overexpression) of PTP1B in muscle associated with targeted disruption
4) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.04 Pain Relevance 0.15

General Comments

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