INT253106

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.62
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
heart 2
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 17 94.36 High High
agonist 29 92.20 High High
Inflammation 39 91.24 High High
Kinase C 4 88.24 High High
cOX1 1 83.68 Quite High
cytokine 22 81.16 Quite High
psoriasis 63 77.28 Quite High
pruritus 1 73.72 Quite High
headache 2 73.32 Quite High
metalloproteinase 1 68.88 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 97 99.92 Very High Very High Very High
Targeted Disruption 26 99.44 Very High Very High Very High
Obesity 48 97.88 Very High Very High Very High
Impaired Glucose Tolerance 12 94.36 High High
Disorder Of Lipid Metabolism 33 93.68 High High
Toxicity 6 93.20 High High
Acromegaly 36 92.48 High High
Metabolic Syndrome 25 92.08 High High
INFLAMMATION 40 91.24 High High
Liver Disease 18 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with previous report, HepG2 cells exposed to high glucose concentration (25 mM) exhibited reduced insulin-stimulated Akt phosphorylation (Fig. 8A, [34]).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of insulin
1) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.73 Pain Relevance 0
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Negative_regulation (recovery) of Phosphorylation (phosphorylation) of insulin
2) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.45 Pain Relevance 0.29
Moreover, GH also inhibits the phosphorylation of one of the proximate molecules of the insulin signaling cascade, insulin receptor substrate-1 in response to insulin (Kuhn et al 1992).
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of insulin
3) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 1.42 Pain Relevance 0.25
Further, even though complete knockout of PTEN in muscle led to a reduction in insulin-stimulated phosphorylation of PKB in the EDL and increased wet mass in the TA and heart, the response to overload was unaltered.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of insulin in heart associated with targeted disruption
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.16 Pain Relevance 0
can also lead to insulin resistance by inhibiting phosphorylation of insulin receptor tyrosine and of insulin receptor substrate 1.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of insulin associated with insulin resistance
5) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.74 Pain Relevance 0.23
Activation JNK and/or p38 kinase especially by saturated FFAs and increased ROS [151, 152] leads to serine phosphorylation and inhibition of insulin receptor substrates IRS-1 and IRS-2, resulting in decreased insulin signaling (i.e., decreased Tyrosine phosphorylation) and increased hepatic gluconeogenesis during insulin resistance.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of insulin associated with insulin resistance
6) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.03 Pain Relevance 0.09

General Comments

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