INT253107

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) kinase activity (Stk11)
Stk11 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 12 75.32 Quite High
alcohol 12 50.00 Quite Low
cytokine 17 45.68 Quite Low
agonist 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 40 78.76 Quite High
Impaired Glucose Tolerance 13 75.32 Quite High
Targeted Disruption 8 69.68 Quite High
Coronary Heart Disease 4 50.00 Quite Low
Obesity 22 49.68 Quite Low
Stress 5 29.44 Quite Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Alcoholic Cardiomyopathy 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LKB1 was phosphorylated by IL-6 at Ser431, although the state of phosphorylation of this kinase did not significantly affect LKB1 catalytic activity or its cellular location, as described previously (36).
Neg (not) Regulation (affect) of LKB1
1) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.22 Pain Relevance 0.04
Effect of acute ethanol challenge on AMPK, ACC and LKB1 in FVB and ADH mice
Regulation (Effect) of LKB1
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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