INT253108

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 16
Disease Relevance 2.13
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) kinase activity (Stk11)
Anatomy Link Frequency
plasma 1
Stk11 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 156 90.48 High High
tolerance 96 85.44 High High
ischemia 42 80.52 Quite High
cytokine 51 67.52 Quite High
anesthesia 29 10.16 Low Low
ketamine 39 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 139 93.44 High High
Targeted Disruption 74 91.76 High High
Insulin Resistance 120 85.16 High High
Stress 55 84.32 Quite High
Apoptosis 26 83.44 Quite High
Cv Unclassified Under Development 42 80.52 Quite High
Obesity 86 78.32 Quite High
Coronary Heart Disease 52 75.00 Quite High
Toxicity 91 54.40 Quite High
Hyperinsulinism 19 42.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with its effect on AMPK and ACC phosphorylation, acute ethanol challenge enhanced the phosphorylation of LKB1 (both absolute and pLKB1/LKB1 ratio), the effect of which was augmented by ADH transgene.
Phosphorylation (phosphorylation) of LKB1
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Second, AMP activates the AMPK upstream kinase LKB1 to phosphorylate ?
Phosphorylation (phosphorylate) of LKB1
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.21 Pain Relevance 0.07
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Phosphorylation (phosphorylation) of LKB1
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.41 Pain Relevance 0.08
Although data from our present study fail to provide any precise mechanism of action behind the hyperphosphorylated LKB1/AMPK signaling cascade, accumulation of reactive oxygen species in response to ethanol exposure is believed to play an important role.
Phosphorylation (hyperphosphorylated) of LKB1
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.32 Pain Relevance 0.03
Last but not the least, ADH transgene itself did not affect LKB1 phosphorylation (Fig. 8).


Phosphorylation (phosphorylation) of LKB1
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Result from our current study revealed that acute ethanol treatment turned on LKB1 phosphorylation with a further increase in ADH mice, supporting a likely role of LKB1 in the ADH and ethanol-induced AMPK activation (shown by phosphorylation of AMPK and ACC).
Phosphorylation (phosphorylation) of LKB1
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.12 Pain Relevance 0.03
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of LKB1
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of LKB1
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of LKB1
9) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
, anti-Glut4, anti-AMPK, anti-phosphorylated AMPK (pAMPK, Thr172), anti-ACC, anti-phosphorylated ACC (pACC, Ser79), anti-LKB1, anti-phosphorylated LKB1 (pLKB1, Ser428), anti-PP2AA, anti-PP2AB, anti-PP2C?
Phosphorylation (phosphorylated) of pLKB1
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
LKB1 was phosphorylated by IL-6 at Ser431, although the state of phosphorylation of this kinase did not significantly affect LKB1 catalytic activity or its cellular location, as described previously (36).
Phosphorylation (phosphorylated) of LKB1
11) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.33 Pain Relevance 0.07
We observed that IL-6 induces the sequential phosphorylation of LKB1, AMPK, and AS160.
Phosphorylation (phosphorylation) of LKB1
12) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.33 Pain Relevance 0.07
In line with its effect on AMPK and ACC phosphorylation, acute ethanol challenge enhanced the phosphorylation of LKB1 (both absolute and pLKB1/LKB1 ratio), the effect of which was augmented by ADH transgene.
Phosphorylation (phosphorylation) of pLKB1
13) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
IL-6 treatment for 3 h produced the sequential phosphorylation of LKB1, AMPK, ACC, and AS160 in C2C12 cells, and phosphorylation of ACC and AS160 was prevented by compound C.
Phosphorylation (phosphorylation) of LKB1
14) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.07 Pain Relevance 0.03
, as well as phosphorylation of AMPK, ACC and LKB1, all of which except plasma insulin were overtly accentuated by ADH transgene.
Phosphorylation (phosphorylation) of LKB1 in plasma
15) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.33 Pain Relevance 0.15
In line with its effect on AMPK and ACC phosphorylation, acute ethanol challenge enhanced the phosphorylation of LKB1 (both absolute and pLKB1/LKB1 ratio), the effect of which was augmented by ADH transgene.
Phosphorylation (phosphorylation) of LKB1
16) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0

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