INT253110

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 0.78
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkag1) protein complex (Prkag1) response to stress (Prkag1)
Anatomy Link Frequency
myocardium 6
Prkag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 64.32 Quite High
ischemia 11 57.84 Quite High
fibrosis 21 55.04 Quite High
cytokine 18 52.84 Quite High
alcohol 36 50.00 Quite Low
tolerance 25 44.04 Quite Low
agonist 33 41.64 Quite Low
anesthesia 13 20.36 Low Low
ketamine 13 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 36 79.12 Quite High
Cancer 4 71.60 Quite High
Coronary Heart Disease 39 71.04 Quite High
Diabetes Mellitus 20 58.12 Quite High
Cv Unclassified Under Development 11 57.84 Quite High
Fibrosis 21 55.04 Quite High
Obesity 33 53.76 Quite High
Left Ventricular Hypertrophy 20 50.00 Quite Low
Metabolic Syndrome 13 48.36 Quite Low
Insulin Resistance 55 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Result from our current study revealed that acute ethanol treatment turned on LKB1 phosphorylation with a further increase in ADH mice, supporting a likely role of LKB1 in the ADH and ethanol-induced AMPK activation (shown by phosphorylation of AMPK and ACC).
Positive_regulation (induced) of Positive_regulation (activation) of AMPK
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.11 Pain Relevance 0.03
We went on to examine the involvement of LKB1 in ADH and ethanol-induced response in AMPK/ACC activation.
Positive_regulation (induced) of Positive_regulation (activation) of AMPK
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Elevated level of AMP induces allosteric stimulation of AMPK.
Positive_regulation (induces) of Positive_regulation (stimulation) of AMPK
3) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.13 Pain Relevance 0.03
To further explore the mechanism of action behind ADH and/or ethanol-induced response in AMPK activation, expression of protein phosphatase PP2A (both PP2AA and PP2AB) and PP2C was examined in FVB and ADH myocardium with or without acute ethanol challenge.
Positive_regulation (induced) of Positive_regulation (activation) of AMPK in myocardium
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
These data seem to indicate that activation of glucose uptake by IL-6 is dependent on the activation of AMPK.
Positive_regulation (dependent) of Positive_regulation (activation) of AMPK
5) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0 Pain Relevance 0.03
It is possible that the activation of AMPK induced by the raise in the AMP:ATP relative amount may inhibit the mTOR/S6K complex in the overloaded myocardium[32].
Spec (possible) Positive_regulation (activation) of Positive_regulation (induced) of AMPK in myocardium
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.27 Pain Relevance 0.03
It is possible that the activation of AMPK induced by the raise in the AMP:ATP relative amount may inhibit the mTOR/S6K complex in the overloaded myocardium[32].
Positive_regulation (induced) of Spec (possible) Positive_regulation (activation) of AMPK in myocardium
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox