INT253114

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.48
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
Anatomy Link Frequency
macrophages 2
axial skeleton 1
muscle 1
myotubes 1
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 124 100.00 Very High Very High Very High
metalloproteinase 7 100.00 Very High Very High Very High
agonist 71 91.92 High High
Inflammation 29 89.84 High High
tolerance 60 65.72 Quite High
Spinal cord 4 32.40 Quite Low
Central nervous system 15 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Kinase C 7 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 301 98.00 Very High Very High Very High
Scoliosis 314 97.36 Very High Very High Very High
Obesity 325 93.52 High High
Thymoma 3 90.16 High High
INFLAMMATION 30 89.84 High High
Hyperinsulinism 17 79.52 Quite High
Body Weight 30 77.60 Quite High
Disorder Of Lipid Metabolism 33 76.32 Quite High
Impaired Glucose Tolerance 39 65.72 Quite High
Hyperglycemia 16 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Positive_regulation (induced) of ptp1b in macrophages associated with metalloproteinase and cytokine
1) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.59 Pain Relevance 0.33
Moreover, an enhancement of PTP1B protein content in muscle was found in IL-6–treated wild-type mice.
Positive_regulation (enhancement) of PTP1B protein in muscle
2) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.42 Pain Relevance 0.11
In this regard, activation of JNK1/2, accumulation of socs3 mRNA, and increases in ptp1b mRNA and activity were detected in murine myotubes.
Positive_regulation (increases) of ptp1b in myotubes
3) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.78 Pain Relevance 0.04
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Positive_regulation (activation) of ptp1b in macrophages associated with metalloproteinase and cytokine
4) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.61 Pain Relevance 0.33
We did not detect changes in ptp1b expression by IL-6 treatment at 3 or 6 h (data not shown), but at 24 h, a significant increase on ptp1b mRNA accumulation and activity was observed (Fig. 4D and E).
Positive_regulation (increase) of ptp1b
5) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.44 Pain Relevance 0.04
Because activation of PTP1B can contribute to TNF-?
Positive_regulation (activation) of PTP1B
6) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.36 Pain Relevance 0.07
We did not detect changes in ptp1b expression by IL-6 treatment at 3 or 6 h (data not shown), but at 24 h, a significant increase on ptp1b mRNA accumulation and activity was observed (Fig. 4D and E).
Positive_regulation (accumulation) of ptp1b
7) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.44 Pain Relevance 0.04
polypeptide (PIK3CD), and protein tyrosine phosphatase nonreceptor type 1(PTPN1,PTP1B), all of which are involved in the insulin signaling pathway, were not markedly upregulated or downregulated.
Neg (not) Positive_regulation (upregulated) of PTP1B
8) Confidence 0.34 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.30 Pain Relevance 0
polypeptide (PIK3CD), and protein tyrosine phosphatase nonreceptor type 1(PTPN1,PTP1B), all of which are involved in the insulin signaling pathway, were not markedly upregulated or downregulated.
Neg (not) Positive_regulation (upregulated) of protein tyrosine phosphatase nonreceptor type 1
9) Confidence 0.34 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.31 Pain Relevance 0
polypeptide (PIK3CD), and protein tyrosine phosphatase nonreceptor type 1(PTPN1,PTP1B), all of which are involved in the insulin signaling pathway, were not markedly upregulated or downregulated.
Neg (not) Positive_regulation (upregulated) of PTPN1
10) Confidence 0.34 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.30 Pain Relevance 0
The autonomic component of this double neuro-osseous theory for AIS pathogenesis in girls involves selectively increased sensitivity of the hypothalamus to circulating leptin (genetically-determined up-regulation possibly involving inhibitory or sensitizing intracellular molecules, such as SOC3, PTP-1B and SH2B1 respectively), with asymmetry as an adverse response (hormesis); this asymmetry is routed bilaterally via the sympathetic nervous system to the growing axial skeleton where it may initiate the scoliosis deformity (leptin-hypothalamic-sympathetic nervous system concept = LHS concept).
Positive_regulation (up-regulation) of PTP-1B in axial skeleton associated with scoliosis
11) Confidence 0.19 Published 2009 Journal Scoliosis Section Abstract Doc Link PMC2781798 Disease Relevance 0.94 Pain Relevance 0

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