INT253118

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) transmembrane transporter activity (Slc2a4)
plasma membrane (Slc2a4) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
myotubes 4
skeletal muscle 2
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 44 99.56 Very High Very High Very High
cytokine 38 97.10 Very High Very High Very High
agonist 20 51.84 Quite High
Inflammation 14 15.36 Low Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 82 99.96 Very High Very High Very High
Impaired Glucose Tolerance 64 99.56 Very High Very High Very High
Aging 38 98.72 Very High Very High Very High
Cancer 10 93.12 High High
Necrosis 10 92.64 High High
Parkinson's Disease 4 75.48 Quite High
Disease 6 73.80 Quite High
Obesity 74 70.36 Quite High
Diabetes Mellitus 98 69.88 Quite High
Apoptosis 8 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A dual effect on insulin action was observed when myotubes and mice were exposed to this cytokine: additive with short-term insulin (increased glucose uptake and systemic insulin sensitivity) but chronic exposure produced insulin resistance (impaired GLUT4 translocation to plasma membrane and defects in insulin signaling at the insulin receptor substrate 1 [IRS-1] level).
Negative_regulation (impaired) of Localization (translocation) of GLUT4 in myotubes associated with insulin resistance and cytokine
1) Confidence 0.25 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584126 Disease Relevance 0.40 Pain Relevance 0.15
Chronic exposure (24 h) to IL-6 impaired insulin-stimulated glucose uptake and GLUT4 translocation in both C2C12 and neonatal myotubes.
Negative_regulation (impaired) of Localization (translocation) of GLUT4 in myotubes
2) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.23 Pain Relevance 0.07
Serine kinases impede insulin signaling by reducing IRS phosphorylation [64, 65, 72] which leads to a decline in insulin-stimulated GLUT4 translocation and impaired skeletal muscle glucose uptake [64, 65].

3.4.

Negative_regulation (decline) of Localization (translocation) of GLUT4 in skeletal muscle
3) Confidence 0.10 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.97 Pain Relevance 0.03
Importantly, older adults with diminished glucose tolerance do not demonstrate a decline in exercise-induced contractile-mediated GLUT4 translocation [59].

3.2.

Negative_regulation (decline) of Localization (translocation) of GLUT4 associated with tolerance and impaired glucose tolerance
4) Confidence 0.10 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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